Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand

This study was performed to investigate the dose-response relationship between average daily cadmium dose (ADCD) from rice and the occurrence of urinary cadmium (U-Cd) in individuals eating that rice. This was a retrospective cohort designed to compare populations from two areas with different level...

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Main Authors: Aroon La-Up, Phongtape Wiwatanadate, Sakda Pruenglampoo, Sureeporn Uthaikhup
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/43598
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-435982018-04-25T07:37:28Z Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand Aroon La-Up Phongtape Wiwatanadate Sakda Pruenglampoo Sureeporn Uthaikhup Environmental Science Agricultural and Biological Sciences Arts and Humanities This study was performed to investigate the dose-response relationship between average daily cadmium dose (ADCD) from rice and the occurrence of urinary cadmium (U-Cd) in individuals eating that rice. This was a retrospective cohort designed to compare populations from two areas with different levels of cadmium contamination. Five-hundred and sixty-seven participants aged 18 years or older were interviewed to estimate their rice intake, and were assessed for U-Cd. The sources of consumed rice were sampled for cadmium measurement, from which the ADCD was estimated. Binary logistic regression was used to examine the association between ADCD and U-Cd (cut-offpoint at 2 μg/g creatinine), and a correlation between them was established. The lowest estimate was ADCD = 0.5 μg/kg bw/day [odds ratio (OR) = 1.71; with a 95% confidence interval (CI) 1.02-2.87]. For comparison, the relationship in the contaminated area is expressed by ADCD = 0.7 μg/kg bw/day, OR = 1.84; [95 % CI, 1.06-3.19] , while no relationship was found in the non-contaminated area, meaning that the highest level at which this relationship does not exist is ADCD = 0.6 μg/kg bw/day [95% CI, 0.99-2.95]. Rice, as a main staple food, is the most likely source of dietary cadmium. Abstaining from or limiting rice consumption, therefore, will increase the likelihood of maintaining U-Cd within the normal range. As the recommended maximum ADCD is not to exceed 0.6 μg/kg bw/day, the consumption of rice grown in cadmium-contaminated areas should not be more than 246.8 g/day. However, the exclusion of many edible plants grown in the contaminated area from the analysis might result in an estimated ADCD that does not reflect the true level of cadmium exposure among local people. 2018-01-24T03:50:33Z 2018-01-24T03:50:33Z 2017-10-01 Journal 22342753 19768257 2-s2.0-85033359892 10.5487/TR.2017.33.4.291 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033359892&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43598
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Environmental Science
Agricultural and Biological Sciences
Arts and Humanities
spellingShingle Environmental Science
Agricultural and Biological Sciences
Arts and Humanities
Aroon La-Up
Phongtape Wiwatanadate
Sakda Pruenglampoo
Sureeporn Uthaikhup
Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand
description This study was performed to investigate the dose-response relationship between average daily cadmium dose (ADCD) from rice and the occurrence of urinary cadmium (U-Cd) in individuals eating that rice. This was a retrospective cohort designed to compare populations from two areas with different levels of cadmium contamination. Five-hundred and sixty-seven participants aged 18 years or older were interviewed to estimate their rice intake, and were assessed for U-Cd. The sources of consumed rice were sampled for cadmium measurement, from which the ADCD was estimated. Binary logistic regression was used to examine the association between ADCD and U-Cd (cut-offpoint at 2 μg/g creatinine), and a correlation between them was established. The lowest estimate was ADCD = 0.5 μg/kg bw/day [odds ratio (OR) = 1.71; with a 95% confidence interval (CI) 1.02-2.87]. For comparison, the relationship in the contaminated area is expressed by ADCD = 0.7 μg/kg bw/day, OR = 1.84; [95 % CI, 1.06-3.19] , while no relationship was found in the non-contaminated area, meaning that the highest level at which this relationship does not exist is ADCD = 0.6 μg/kg bw/day [95% CI, 0.99-2.95]. Rice, as a main staple food, is the most likely source of dietary cadmium. Abstaining from or limiting rice consumption, therefore, will increase the likelihood of maintaining U-Cd within the normal range. As the recommended maximum ADCD is not to exceed 0.6 μg/kg bw/day, the consumption of rice grown in cadmium-contaminated areas should not be more than 246.8 g/day. However, the exclusion of many edible plants grown in the contaminated area from the analysis might result in an estimated ADCD that does not reflect the true level of cadmium exposure among local people.
format Journal
author Aroon La-Up
Phongtape Wiwatanadate
Sakda Pruenglampoo
Sureeporn Uthaikhup
author_facet Aroon La-Up
Phongtape Wiwatanadate
Sakda Pruenglampoo
Sureeporn Uthaikhup
author_sort Aroon La-Up
title Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand
title_short Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand
title_full Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand
title_fullStr Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand
title_full_unstemmed Recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern Thailand
title_sort recommended rice intake levels based on average daily dose and urinary excretion of cadmium in a cadmium-contaminated area of northwestern thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033359892&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43598
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