Oxidative stress in oral diseases: Understanding its relation with other systemic diseases

© 2017 Kumar, Teoh, Das and Mahakknaukrauh. Oxidative stress occurs in diabetes, various cancers, liver diseases, stroke, rheumatoid arthritis, chronic inflammation, and other degenerative diseases related to the nervous system. The free radicals have deleterious effect on various organs of the body...

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Main Authors: Jaya Kumar, Seong Lin Teoh, Srijit Das, Pasuk Mahakknaukrauh
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/43638
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-436382018-04-25T07:16:22Z Oxidative stress in oral diseases: Understanding its relation with other systemic diseases Jaya Kumar Seong Lin Teoh Srijit Das Pasuk Mahakknaukrauh Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences © 2017 Kumar, Teoh, Das and Mahakknaukrauh. Oxidative stress occurs in diabetes, various cancers, liver diseases, stroke, rheumatoid arthritis, chronic inflammation, and other degenerative diseases related to the nervous system. The free radicals have deleterious effect on various organs of the body. This is due to lipid peroxidation and irreversible protein modification that leads to cellular apoptosis or programmed cell death. During recent years, there is a rise in the oral diseases related to oxidative stress. Oxidative stress in oral disease is related to other systemic diseases in the body such as periodontitis, cardiovascular, pancreatic, gastric, and liver diseases. In the present review, we discuss the various pathways that mediate oxidative cellular damage. Numerous pathways mediate oxidative cellular damage and these include caspase pathway, PERK/NRF2 pathway, NADPH oxidase 4 pathways and JNK/mitogen-activated protein (MAP) kinase pathway. We also discuss the role of inflammatory markers, lipid peroxidation, and role of oxygen species linked to oxidative stress. Knowledge of different pathways, role of inflammatory markers, and importance of low-density lipoprotein, fibrinogen, creatinine, nitric oxide, nitrates, and highly sensitive C-reactive proteins may be helpful in understanding the pathogenesis and plan better treatment for oral diseases which involve oxidative stress. 2018-01-24T03:51:10Z 2018-01-24T03:51:10Z 2017-09-14 Journal 1664042X 2-s2.0-85029691928 10.3389/fphys.2017.00693 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029691928&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43638
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Agricultural and Biological Sciences
spellingShingle Biochemistry, Genetics and Molecular Biology
Agricultural and Biological Sciences
Jaya Kumar
Seong Lin Teoh
Srijit Das
Pasuk Mahakknaukrauh
Oxidative stress in oral diseases: Understanding its relation with other systemic diseases
description © 2017 Kumar, Teoh, Das and Mahakknaukrauh. Oxidative stress occurs in diabetes, various cancers, liver diseases, stroke, rheumatoid arthritis, chronic inflammation, and other degenerative diseases related to the nervous system. The free radicals have deleterious effect on various organs of the body. This is due to lipid peroxidation and irreversible protein modification that leads to cellular apoptosis or programmed cell death. During recent years, there is a rise in the oral diseases related to oxidative stress. Oxidative stress in oral disease is related to other systemic diseases in the body such as periodontitis, cardiovascular, pancreatic, gastric, and liver diseases. In the present review, we discuss the various pathways that mediate oxidative cellular damage. Numerous pathways mediate oxidative cellular damage and these include caspase pathway, PERK/NRF2 pathway, NADPH oxidase 4 pathways and JNK/mitogen-activated protein (MAP) kinase pathway. We also discuss the role of inflammatory markers, lipid peroxidation, and role of oxygen species linked to oxidative stress. Knowledge of different pathways, role of inflammatory markers, and importance of low-density lipoprotein, fibrinogen, creatinine, nitric oxide, nitrates, and highly sensitive C-reactive proteins may be helpful in understanding the pathogenesis and plan better treatment for oral diseases which involve oxidative stress.
format Journal
author Jaya Kumar
Seong Lin Teoh
Srijit Das
Pasuk Mahakknaukrauh
author_facet Jaya Kumar
Seong Lin Teoh
Srijit Das
Pasuk Mahakknaukrauh
author_sort Jaya Kumar
title Oxidative stress in oral diseases: Understanding its relation with other systemic diseases
title_short Oxidative stress in oral diseases: Understanding its relation with other systemic diseases
title_full Oxidative stress in oral diseases: Understanding its relation with other systemic diseases
title_fullStr Oxidative stress in oral diseases: Understanding its relation with other systemic diseases
title_full_unstemmed Oxidative stress in oral diseases: Understanding its relation with other systemic diseases
title_sort oxidative stress in oral diseases: understanding its relation with other systemic diseases
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029691928&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43638
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