Monoterpene indole alkaloid azine derivatives as MDR reversal agents

• Main Authors: Angela Paterna, Ruttiros Khonkarn, Silva Mulhovo, Alexis Moreno, Patricia Madeira Girio, Hélène Baubichon-Cortay, Pierre Falson, Maria José U. Ferreira
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85037656553&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/43856
• Institution: Chiang Mai University

© 2017 Elsevier Ltd Aiming at generating a library of bioactive indole alkaloid derivatives as multidrug resistance (MDR) reversers, two epimeric indole alkaloids (1 and 2) were submitted to chemical transformations, giving rise to twenty-four derivatives (5-28), bearing new aromatic or aliphatic az...