Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Respiratory muscle dysfunction is common and contributes to dyspnea and exercise limitation in patients with chronic obstructive pulmonary disease (COPD). Improving dynamic function of respiratory muscles during exerci...

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Main Authors: Noppawan Charususin, Sauwaluk Dacha, Rik Gosselink, Marc Decramer, Andreas Von Leupoldt, Thomas Reijnders, Zafeiris Louvaris, Daniel Langer
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038223568&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43864
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-438642018-01-24T04:14:30Z Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review Noppawan Charususin Sauwaluk Dacha Rik Gosselink Marc Decramer Andreas Von Leupoldt Thomas Reijnders Zafeiris Louvaris Daniel Langer © 2017 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Respiratory muscle dysfunction is common and contributes to dyspnea and exercise limitation in patients with chronic obstructive pulmonary disease (COPD). Improving dynamic function of respiratory muscles during exercise might help to reduce symptoms and improve exercise capacity. Areas covered: The aims of this review are to 1) summarize physiological mechanisms linking respiratory muscle dysfunction to dyspnea and exercise limitation; 2) provide an overview of available therapeutic approaches to better maintain load-capacity balance of respiratory muscles during exercise; and 3) to summarize current knowledge on potential mechanisms explaining effects of interventions aimed at optimizing dynamic respiratory muscle function with a special focus on inspiratory muscle training. Expert commentary: Several mechanisms which are potentially linking improvements in dynamic respiratory muscle function to symptomatic and functional benefits have not been studied so far in COPD patients. Examples of underexplored areas include the study of neural processes related to the relief of acute dyspnea and the competition between respiratory and peripheral muscles for limited energy supplies during exercise. Novel methodologies are available to non-invasively study these mechanisms. Better insights into the consequences of dynamic respiratory muscle dysfunction will hopefully contribute to further refine and individualize therapeutic approaches in patients with COPD. 2018-01-24T04:14:30Z 2018-01-24T04:14:30Z 2018-01-02 Journal 17476356 17476348 2-s2.0-85038223568 10.1080/17476348.2018.1398084 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038223568&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43864
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Respiratory muscle dysfunction is common and contributes to dyspnea and exercise limitation in patients with chronic obstructive pulmonary disease (COPD). Improving dynamic function of respiratory muscles during exercise might help to reduce symptoms and improve exercise capacity. Areas covered: The aims of this review are to 1) summarize physiological mechanisms linking respiratory muscle dysfunction to dyspnea and exercise limitation; 2) provide an overview of available therapeutic approaches to better maintain load-capacity balance of respiratory muscles during exercise; and 3) to summarize current knowledge on potential mechanisms explaining effects of interventions aimed at optimizing dynamic respiratory muscle function with a special focus on inspiratory muscle training. Expert commentary: Several mechanisms which are potentially linking improvements in dynamic respiratory muscle function to symptomatic and functional benefits have not been studied so far in COPD patients. Examples of underexplored areas include the study of neural processes related to the relief of acute dyspnea and the competition between respiratory and peripheral muscles for limited energy supplies during exercise. Novel methodologies are available to non-invasively study these mechanisms. Better insights into the consequences of dynamic respiratory muscle dysfunction will hopefully contribute to further refine and individualize therapeutic approaches in patients with COPD.
format Journal
author Noppawan Charususin
Sauwaluk Dacha
Rik Gosselink
Marc Decramer
Andreas Von Leupoldt
Thomas Reijnders
Zafeiris Louvaris
Daniel Langer
spellingShingle Noppawan Charususin
Sauwaluk Dacha
Rik Gosselink
Marc Decramer
Andreas Von Leupoldt
Thomas Reijnders
Zafeiris Louvaris
Daniel Langer
Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
author_facet Noppawan Charususin
Sauwaluk Dacha
Rik Gosselink
Marc Decramer
Andreas Von Leupoldt
Thomas Reijnders
Zafeiris Louvaris
Daniel Langer
author_sort Noppawan Charususin
title Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
title_short Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
title_full Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
title_fullStr Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
title_full_unstemmed Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
title_sort respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038223568&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43864
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