A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs

© 2017 Elsevier Ltd Drug resistance to Mycobacterium tuberculosis is a major health problem worldwide. Mycobacterium tuberculosis can progress to be mono-drug resistant or multi-drug resistant by improper treatment. The chemical stress of M. tuberculosis was performed in this study. Rv0559c is an un...

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Main Authors: Ratikorn Gamngoen, Chanyanuch Putim, Parichat Salee, Ponrut Phunpae, Bordin Butr-Indr
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032943312&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43893
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-438932018-01-24T04:14:49Z A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs Ratikorn Gamngoen Chanyanuch Putim Parichat Salee Ponrut Phunpae Bordin Butr-Indr © 2017 Elsevier Ltd Drug resistance to Mycobacterium tuberculosis is a major health problem worldwide. Mycobacterium tuberculosis can progress to be mono-drug resistant or multi-drug resistant by improper treatment. The chemical stress of M. tuberculosis was performed in this study. Rv0559c is an unknown secreted protein. Rv0560c is a putative benzoquinone methyltransferase of M. tuberculosis cell. Rv0559c gene is located downstream of Rv0560c gene. Both genes respond to salicylate stress. Drug susceptible, isoniazid resistant, rifampicin resistant and multi-drug resistant phenotypes of M. tuberculosis clinical isolates were used to determine the expression of Rv0559c and Rv0560c by qRT-PCR. In all of mycobacteria strains there was up-regulation in both genes when stressed with isoniazid. This study determined the expression of both genes, which may play important roles in the drug resistance mechanism of mycobacteria. 2018-01-24T04:14:49Z 2018-01-24T04:14:49Z 2018-01-01 Journal 1873281X 14729792 2-s2.0-85032943312 10.1016/j.tube.2017.11.002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032943312&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43893
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017 Elsevier Ltd Drug resistance to Mycobacterium tuberculosis is a major health problem worldwide. Mycobacterium tuberculosis can progress to be mono-drug resistant or multi-drug resistant by improper treatment. The chemical stress of M. tuberculosis was performed in this study. Rv0559c is an unknown secreted protein. Rv0560c is a putative benzoquinone methyltransferase of M. tuberculosis cell. Rv0559c gene is located downstream of Rv0560c gene. Both genes respond to salicylate stress. Drug susceptible, isoniazid resistant, rifampicin resistant and multi-drug resistant phenotypes of M. tuberculosis clinical isolates were used to determine the expression of Rv0559c and Rv0560c by qRT-PCR. In all of mycobacteria strains there was up-regulation in both genes when stressed with isoniazid. This study determined the expression of both genes, which may play important roles in the drug resistance mechanism of mycobacteria.
format Journal
author Ratikorn Gamngoen
Chanyanuch Putim
Parichat Salee
Ponrut Phunpae
Bordin Butr-Indr
spellingShingle Ratikorn Gamngoen
Chanyanuch Putim
Parichat Salee
Ponrut Phunpae
Bordin Butr-Indr
A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
author_facet Ratikorn Gamngoen
Chanyanuch Putim
Parichat Salee
Ponrut Phunpae
Bordin Butr-Indr
author_sort Ratikorn Gamngoen
title A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
title_short A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
title_full A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
title_fullStr A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
title_full_unstemmed A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
title_sort comparison of rv0559c and rv0560c expression in drug-resistant mycobacterium tuberculosis in response to first-line antituberculosis drugs
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032943312&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43893
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