A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs
© 2017 Elsevier Ltd Drug resistance to Mycobacterium tuberculosis is a major health problem worldwide. Mycobacterium tuberculosis can progress to be mono-drug resistant or multi-drug resistant by improper treatment. The chemical stress of M. tuberculosis was performed in this study. Rv0559c is an un...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032943312&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43893 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-43893 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-438932018-01-24T04:14:49Z A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs Ratikorn Gamngoen Chanyanuch Putim Parichat Salee Ponrut Phunpae Bordin Butr-Indr © 2017 Elsevier Ltd Drug resistance to Mycobacterium tuberculosis is a major health problem worldwide. Mycobacterium tuberculosis can progress to be mono-drug resistant or multi-drug resistant by improper treatment. The chemical stress of M. tuberculosis was performed in this study. Rv0559c is an unknown secreted protein. Rv0560c is a putative benzoquinone methyltransferase of M. tuberculosis cell. Rv0559c gene is located downstream of Rv0560c gene. Both genes respond to salicylate stress. Drug susceptible, isoniazid resistant, rifampicin resistant and multi-drug resistant phenotypes of M. tuberculosis clinical isolates were used to determine the expression of Rv0559c and Rv0560c by qRT-PCR. In all of mycobacteria strains there was up-regulation in both genes when stressed with isoniazid. This study determined the expression of both genes, which may play important roles in the drug resistance mechanism of mycobacteria. 2018-01-24T04:14:49Z 2018-01-24T04:14:49Z 2018-01-01 Journal 1873281X 14729792 2-s2.0-85032943312 10.1016/j.tube.2017.11.002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032943312&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43893 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
description |
© 2017 Elsevier Ltd Drug resistance to Mycobacterium tuberculosis is a major health problem worldwide. Mycobacterium tuberculosis can progress to be mono-drug resistant or multi-drug resistant by improper treatment. The chemical stress of M. tuberculosis was performed in this study. Rv0559c is an unknown secreted protein. Rv0560c is a putative benzoquinone methyltransferase of M. tuberculosis cell. Rv0559c gene is located downstream of Rv0560c gene. Both genes respond to salicylate stress. Drug susceptible, isoniazid resistant, rifampicin resistant and multi-drug resistant phenotypes of M. tuberculosis clinical isolates were used to determine the expression of Rv0559c and Rv0560c by qRT-PCR. In all of mycobacteria strains there was up-regulation in both genes when stressed with isoniazid. This study determined the expression of both genes, which may play important roles in the drug resistance mechanism of mycobacteria. |
format |
Journal |
author |
Ratikorn Gamngoen Chanyanuch Putim Parichat Salee Ponrut Phunpae Bordin Butr-Indr |
spellingShingle |
Ratikorn Gamngoen Chanyanuch Putim Parichat Salee Ponrut Phunpae Bordin Butr-Indr A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs |
author_facet |
Ratikorn Gamngoen Chanyanuch Putim Parichat Salee Ponrut Phunpae Bordin Butr-Indr |
author_sort |
Ratikorn Gamngoen |
title |
A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs |
title_short |
A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs |
title_full |
A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs |
title_fullStr |
A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs |
title_full_unstemmed |
A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs |
title_sort |
comparison of rv0559c and rv0560c expression in drug-resistant mycobacterium tuberculosis in response to first-line antituberculosis drugs |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032943312&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43893 |
_version_ |
1681422458215727104 |