Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities

Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities

© 2017 Elsevier B.V. Four new naphthoquinones (1–4), named rhinacanthins S (1), T (2), U (3) and V (4), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and...

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Main Authors: Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat Trisuwan
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034591184&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43907
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-439072018-01-24T04:15:01Z Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan © 2017 Elsevier B.V. Four new naphthoquinones (1–4), named rhinacanthins S (1), T (2), U (3) and V (4), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy and mass spectrometry. Rhinacanthin S (1) exhibited acetylcholinesterase inhibition activity with a % inhibition value of 48.04 ± 3.25. The known rhinacanthin A (5) showed cytotoxicity against a MCF-7 cell line with an IC 50 value of 8.79 μM, while rhinacanthin N (15) was active against the NCI-H187 cell line with an IC 50 = 2.24 μM and Vero cells (IC 50 = 3.00 μM) 2018-01-24T04:15:01Z 2018-01-24T04:15:01Z 2018-01-01 Journal 18736971 0367326X 2-s2.0-85034591184 10.1016/j.fitote.2017.11.011 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034591184&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43907
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017 Elsevier B.V. Four new naphthoquinones (1–4), named rhinacanthins S (1), T (2), U (3) and V (4), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy and mass spectrometry. Rhinacanthin S (1) exhibited acetylcholinesterase inhibition activity with a % inhibition value of 48.04 ± 3.25. The known rhinacanthin A (5) showed cytotoxicity against a MCF-7 cell line with an IC 50 value of 8.79 μM, while rhinacanthin N (15) was active against the NCI-H187 cell line with an IC 50 = 2.24 μM and Vero cells (IC 50 = 3.00 μM)
format Journal
author Sirada Boonyaketgoson
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Kongkiat Trisuwan
spellingShingle Sirada Boonyaketgoson
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Kongkiat Trisuwan
Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
author_facet Sirada Boonyaketgoson
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Kongkiat Trisuwan
author_sort Sirada Boonyaketgoson
title Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_short Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_full Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_fullStr Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_full_unstemmed Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
title_sort naphthoquinones from the leaves of rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034591184&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43907
_version_ 1681422460799418368

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