Current and future treatment strategies for iron overload cardiomyopathy

© 2015 Elsevier B.V. All rights reserved. Iron overload cardiomyopathy is the major cause of death in transfusion-dependent thalassemia (TDT) patients. Growing evidence demonstrates that combined iron chelators, or the combination of an iron chelator with antioxidant(s) are effective in diminishing...

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Main Authors: Suwakon Wongjaikam, Sirinart Kumfu, Siriporn C. Chattipakorn, Suthat Fucharoen, Nipon Chattipakorn
Format: Journal
Published: 2018
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940040361&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44133
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-441332018-04-25T07:46:04Z Current and future treatment strategies for iron overload cardiomyopathy Suwakon Wongjaikam Sirinart Kumfu Siriporn C. Chattipakorn Suthat Fucharoen Nipon Chattipakorn Agricultural and Biological Sciences © 2015 Elsevier B.V. All rights reserved. Iron overload cardiomyopathy is the major cause of death in transfusion-dependent thalassemia (TDT) patients. Growing evidence demonstrates that combined iron chelators, or the combination of an iron chelator with antioxidant(s) are effective in diminishing myocardial iron deposition and attenuating cardiac dysfunction. This review comprehensively summarizes basic and clinical reports on the therapeutic efficacy of combined iron chelators, or the combination of an iron chelator with antioxidant(s) on the heart. Promising benefits of these treatments in preventing cardiac dysfunction due to iron overload could provide extensive insight into future therapeutic strategies for better treatment and prevention of cardiomyopathy in TDT patients. 2018-01-24T04:38:30Z 2018-01-24T04:38:30Z 2015-10-15 Journal 18790712 00142999 2-s2.0-84940040361 10.1016/j.ejphar.2015.08.017 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940040361&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44133
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Suwakon Wongjaikam
Sirinart Kumfu
Siriporn C. Chattipakorn
Suthat Fucharoen
Nipon Chattipakorn
Current and future treatment strategies for iron overload cardiomyopathy
description © 2015 Elsevier B.V. All rights reserved. Iron overload cardiomyopathy is the major cause of death in transfusion-dependent thalassemia (TDT) patients. Growing evidence demonstrates that combined iron chelators, or the combination of an iron chelator with antioxidant(s) are effective in diminishing myocardial iron deposition and attenuating cardiac dysfunction. This review comprehensively summarizes basic and clinical reports on the therapeutic efficacy of combined iron chelators, or the combination of an iron chelator with antioxidant(s) on the heart. Promising benefits of these treatments in preventing cardiac dysfunction due to iron overload could provide extensive insight into future therapeutic strategies for better treatment and prevention of cardiomyopathy in TDT patients.
format Journal
author Suwakon Wongjaikam
Sirinart Kumfu
Siriporn C. Chattipakorn
Suthat Fucharoen
Nipon Chattipakorn
author_facet Suwakon Wongjaikam
Sirinart Kumfu
Siriporn C. Chattipakorn
Suthat Fucharoen
Nipon Chattipakorn
author_sort Suwakon Wongjaikam
title Current and future treatment strategies for iron overload cardiomyopathy
title_short Current and future treatment strategies for iron overload cardiomyopathy
title_full Current and future treatment strategies for iron overload cardiomyopathy
title_fullStr Current and future treatment strategies for iron overload cardiomyopathy
title_full_unstemmed Current and future treatment strategies for iron overload cardiomyopathy
title_sort current and future treatment strategies for iron overload cardiomyopathy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940040361&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44133
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