Inhibitory effect of turmeric curcuminoids on FLT3 expression and cell cycle arrest in the FLT3-overexpressing EoL-1 leukemic cell line

• Main Authors: Tima S., Ichikawa H., Ampasavate C., Okonogi S., Anuchapreeda S.
• Format: Article
• Language: English
• Published: American Chemical Society 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899575129&partnerID=40&md5=ae28f5cca20a8a39e0d7fe68c6827164; http://cmuir.cmu.ac.th/handle/6653943832/4419
• Institution: Chiang Mai University

Leukemia is a hematologic malignancy with a frequent incidence and high mortality rate. Previous studies have shown that the FLT3 gene is overexpressed in leukemic blast cells, especially in acute myeloid leukemia. In this study, a commercially available curcuminoid mixture (1), pure curcumin (2), p...