Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients

© 2015 Informa Healthcare USA, Inc. Iron overload cardiomyopathy remains the major cause of death in β-thalassemia (β-thal). Conventional routine screening parameters such as serum ferritin and echocardiogram (ECG) do not permit early detection of this condition. Although non-transferrin-bound iron...

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Main Authors: Nut Koonrungsesomboon, Adisak Tantiworawit, Arintaya Phrommintikul, Suwit Saekho, Somdet Srichairattanakool, Nipon Chattipakorn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/44406
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spelling th-cmuir.6653943832-444062018-04-25T07:50:41Z Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients Nut Koonrungsesomboon Adisak Tantiworawit Arintaya Phrommintikul Suwit Saekho Somdet Srichairattanakool Nipon Chattipakorn Agricultural and Biological Sciences © 2015 Informa Healthcare USA, Inc. Iron overload cardiomyopathy remains the major cause of death in β-thalassemia (β-thal). Conventional routine screening parameters such as serum ferritin and echocardiogram (ECG) do not permit early detection of this condition. Although non-transferrin-bound iron (NTBI) is a reliable indicator for iron overload, it is still not universally available. Recently, heart rate variability (HRV), representing cardiac autonomic function, was found to be depressed in thalassemia patients. We hypothesized that HRV can be used for early detection of iron overload cardiomyopathy. Fifty patients (aged 29 ± 11 years; 31 females and 19 males) with β-thal were enrolled. The 24-hour Holter monitoring for HRV, serum ferritin, NTBI, hematological values and ECG were performed for each patient. Of the 50 patients, 29 carried β-thal major (β-TM). Non-transferrin-bound iron was weakly correlated to all time-domain HRV parameters. Low- and high-frequency domain HRV parameters were also inversely weakly correlated with NTBI. Neither HRV nor NTBI was correlated with serum ferritin. With its weak but significant correlation with NTBI, HRV may be considered to be used as a potential indicator of an iron overload condition and an early marker of cardiac involvement in patients with β-thal. 2018-01-24T04:42:23Z 2018-01-24T04:42:23Z 2015-01-01 Journal 1532432X 03630269 2-s2.0-84939420029 10.3109/03630269.2015.1043059 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939420029&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44406
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Nut Koonrungsesomboon
Adisak Tantiworawit
Arintaya Phrommintikul
Suwit Saekho
Somdet Srichairattanakool
Nipon Chattipakorn
Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
description © 2015 Informa Healthcare USA, Inc. Iron overload cardiomyopathy remains the major cause of death in β-thalassemia (β-thal). Conventional routine screening parameters such as serum ferritin and echocardiogram (ECG) do not permit early detection of this condition. Although non-transferrin-bound iron (NTBI) is a reliable indicator for iron overload, it is still not universally available. Recently, heart rate variability (HRV), representing cardiac autonomic function, was found to be depressed in thalassemia patients. We hypothesized that HRV can be used for early detection of iron overload cardiomyopathy. Fifty patients (aged 29 ± 11 years; 31 females and 19 males) with β-thal were enrolled. The 24-hour Holter monitoring for HRV, serum ferritin, NTBI, hematological values and ECG were performed for each patient. Of the 50 patients, 29 carried β-thal major (β-TM). Non-transferrin-bound iron was weakly correlated to all time-domain HRV parameters. Low- and high-frequency domain HRV parameters were also inversely weakly correlated with NTBI. Neither HRV nor NTBI was correlated with serum ferritin. With its weak but significant correlation with NTBI, HRV may be considered to be used as a potential indicator of an iron overload condition and an early marker of cardiac involvement in patients with β-thal.
format Journal
author Nut Koonrungsesomboon
Adisak Tantiworawit
Arintaya Phrommintikul
Suwit Saekho
Somdet Srichairattanakool
Nipon Chattipakorn
author_facet Nut Koonrungsesomboon
Adisak Tantiworawit
Arintaya Phrommintikul
Suwit Saekho
Somdet Srichairattanakool
Nipon Chattipakorn
author_sort Nut Koonrungsesomboon
title Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
title_short Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
title_full Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
title_fullStr Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
title_full_unstemmed Heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
title_sort heart rate variability for early detection of iron overload cardiomyopathy in β-thalassemia patients
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939420029&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44406
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