Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities

Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities

© 2015, Japanese Circulation Society. All rights reserved. Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic...

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Main Author: Suree Lekawanvijit
Format: Journal
Published: 2018
Subjects:
Agricultural and Biological Sciences
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942540625&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44480
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-444802018-04-25T07:51:46Z Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities Suree Lekawanvijit Agricultural and Biological Sciences © 2015, Japanese Circulation Society. All rights reserved. Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic toxins (PBUTs) by current conventional dialysis remains problematic because of their proteinbinding capacity. Most PBUTs that have been implicated in cardiorenal toxicity have been demonstrated to be derived from a colonic microbiota metabolism pathway using dietary amino acids as a substrate. Currently, indoxyl sulfate and p-cresyl sulfate are the most extensively investigated gut-derived PBUTs. Strong evidence of adverse clinical outcomes, as well as biological toxicity on the kidney and cardiovascular system attributable to these toxins, has been increasingly reported. Regarding their site of origin, the colon has become a potential target for treatment of cardiorenal syndrome induced by gut-derived PBUTs. 2018-01-24T04:43:32Z 2018-01-24T04:43:32Z 2015-01-01 Journal 13474820 13469843 2-s2.0-84942540625 10.1253/circj.CJ-15-0749 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942540625&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44480
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Suree Lekawanvijit
Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
description © 2015, Japanese Circulation Society. All rights reserved. Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic toxins (PBUTs) by current conventional dialysis remains problematic because of their proteinbinding capacity. Most PBUTs that have been implicated in cardiorenal toxicity have been demonstrated to be derived from a colonic microbiota metabolism pathway using dietary amino acids as a substrate. Currently, indoxyl sulfate and p-cresyl sulfate are the most extensively investigated gut-derived PBUTs. Strong evidence of adverse clinical outcomes, as well as biological toxicity on the kidney and cardiovascular system attributable to these toxins, has been increasingly reported. Regarding their site of origin, the colon has become a potential target for treatment of cardiorenal syndrome induced by gut-derived PBUTs.
format Journal
author Suree Lekawanvijit
author_facet Suree Lekawanvijit
author_sort Suree Lekawanvijit
title Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_short Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_full Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_fullStr Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_full_unstemmed Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_sort role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942540625&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44480
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