Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

© 2015 Wirin Limopasmanee et al. A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover stud...

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Main Authors: Wirin Limopasmanee, Sunee Chansakaow, Noppamas Rojanasthien, Maleeya Manorot, Chaichan Sangdee, Supanimit Teekachunhatean
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/44517
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-445172018-04-25T07:50:39Z Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women Wirin Limopasmanee Sunee Chansakaow Noppamas Rojanasthien Maleeya Manorot Chaichan Sangdee Supanimit Teekachunhatean Agricultural and Biological Sciences © 2015 Wirin Limopasmanee et al. A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed with β-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentration C < inf > max < /inf > , time to reach peak concentration T < inf > max < /inf > , area under the plasma concentration-time curve (AUC), and half-life (t < inf > 1/2 < /inf > ). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens. 2018-01-24T04:44:05Z 2018-01-24T04:44:05Z 2015-01-01 Journal 23146141 23146133 2-s2.0-84934933763 10.1155/2015/902702 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934933763&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44517
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Wirin Limopasmanee
Sunee Chansakaow
Noppamas Rojanasthien
Maleeya Manorot
Chaichan Sangdee
Supanimit Teekachunhatean
Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
description © 2015 Wirin Limopasmanee et al. A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed with β-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentration C < inf > max < /inf > , time to reach peak concentration T < inf > max < /inf > , area under the plasma concentration-time curve (AUC), and half-life (t < inf > 1/2 < /inf > ). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens.
format Journal
author Wirin Limopasmanee
Sunee Chansakaow
Noppamas Rojanasthien
Maleeya Manorot
Chaichan Sangdee
Supanimit Teekachunhatean
author_facet Wirin Limopasmanee
Sunee Chansakaow
Noppamas Rojanasthien
Maleeya Manorot
Chaichan Sangdee
Supanimit Teekachunhatean
author_sort Wirin Limopasmanee
title Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
title_short Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
title_full Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
title_fullStr Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
title_full_unstemmed Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
title_sort effects of the chinese herbal formulation (liu wei di huang wan) on the pharmacokinetics of isoflavones in postmenopausal women
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934933763&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44517
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