Effect of antituberculous drugs on serum uric acid and urine uric acid excretion

© 2015 Wolters Kluwer Health, Inc. All rights reserved. Objectives: The aim of this study was to determine the effect of antituberculous drugs on serum uric acid (SUA), urine uric acid (UUA) excretion, and renal function. Methods: Patients with tuberculosis requiring a 6-month treatment course of an...

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Main Authors: Worawit Louthrenoo, Sith Hongsongkiat, Nuntana Kasitanon, Suparaporn Wangkaew, Kanon Jatuworapruk
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/44543
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-445432018-04-25T07:50:12Z Effect of antituberculous drugs on serum uric acid and urine uric acid excretion Worawit Louthrenoo Sith Hongsongkiat Nuntana Kasitanon Suparaporn Wangkaew Kanon Jatuworapruk Agricultural and Biological Sciences © 2015 Wolters Kluwer Health, Inc. All rights reserved. Objectives: The aim of this study was to determine the effect of antituberculous drugs on serum uric acid (SUA), urine uric acid (UUA) excretion, and renal function. Methods: Patients with tuberculosis requiring a 6-month treatment course of antituberculous drugs (isoniazid, rifampicin, pyrazinamide, and ethambutol for 2 months, followed by isoniazid and rifampicin for a further 4 months) were included in this study. Serum uric acid, 24-hour UUA excretion, uric acid clearance (UACl), serum creatinine, and creatinine clearancewere determined at baseline and at the end of the secondweek, second month, and fourth month. Results: Sixteen of 50 patients completed the study. Their mean ± SD baseline SUA and UACl was 4.44 ± 1.72 mg/dL and 8.77 ± 7.03 mL/min per 1.73 m2, respectively. At the second week, a significant increase in SUA (9.78 ± 3.21 mg/dL, P < 0.001) and significant decrease in UACl (3.50 ± 2.50 mL/min per 1.73 m2, P = 0.001) were noted. These changes persisted through the second month, but returned to baseline value at the fourth month. Thirteen patients (81.25%) had hyperuricemia. The 24-hour UUA followed the same pattern as that of UACl but showed no statistical significance. There were no changes in serum creatinine or creatinine clearance. One patient had arthralgia, and another developed tuberculous arthritis. Conclusions: The hyperuricemic effect of pyrazinamide and ethambutol was due primarily to a decrease in UACl, which was reversible, and had no negative effect on the renal function. Arthralgia was uncommon and required no specific treatment. 2018-01-24T04:44:26Z 2018-01-24T04:44:26Z 2015-01-01 Journal 15367355 10761608 2-s2.0-84942518163 10.1097/RHU.0000000000000297 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942518163&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44543
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Worawit Louthrenoo
Sith Hongsongkiat
Nuntana Kasitanon
Suparaporn Wangkaew
Kanon Jatuworapruk
Effect of antituberculous drugs on serum uric acid and urine uric acid excretion
description © 2015 Wolters Kluwer Health, Inc. All rights reserved. Objectives: The aim of this study was to determine the effect of antituberculous drugs on serum uric acid (SUA), urine uric acid (UUA) excretion, and renal function. Methods: Patients with tuberculosis requiring a 6-month treatment course of antituberculous drugs (isoniazid, rifampicin, pyrazinamide, and ethambutol for 2 months, followed by isoniazid and rifampicin for a further 4 months) were included in this study. Serum uric acid, 24-hour UUA excretion, uric acid clearance (UACl), serum creatinine, and creatinine clearancewere determined at baseline and at the end of the secondweek, second month, and fourth month. Results: Sixteen of 50 patients completed the study. Their mean ± SD baseline SUA and UACl was 4.44 ± 1.72 mg/dL and 8.77 ± 7.03 mL/min per 1.73 m2, respectively. At the second week, a significant increase in SUA (9.78 ± 3.21 mg/dL, P < 0.001) and significant decrease in UACl (3.50 ± 2.50 mL/min per 1.73 m2, P = 0.001) were noted. These changes persisted through the second month, but returned to baseline value at the fourth month. Thirteen patients (81.25%) had hyperuricemia. The 24-hour UUA followed the same pattern as that of UACl but showed no statistical significance. There were no changes in serum creatinine or creatinine clearance. One patient had arthralgia, and another developed tuberculous arthritis. Conclusions: The hyperuricemic effect of pyrazinamide and ethambutol was due primarily to a decrease in UACl, which was reversible, and had no negative effect on the renal function. Arthralgia was uncommon and required no specific treatment.
format Journal
author Worawit Louthrenoo
Sith Hongsongkiat
Nuntana Kasitanon
Suparaporn Wangkaew
Kanon Jatuworapruk
author_facet Worawit Louthrenoo
Sith Hongsongkiat
Nuntana Kasitanon
Suparaporn Wangkaew
Kanon Jatuworapruk
author_sort Worawit Louthrenoo
title Effect of antituberculous drugs on serum uric acid and urine uric acid excretion
title_short Effect of antituberculous drugs on serum uric acid and urine uric acid excretion
title_full Effect of antituberculous drugs on serum uric acid and urine uric acid excretion
title_fullStr Effect of antituberculous drugs on serum uric acid and urine uric acid excretion
title_full_unstemmed Effect of antituberculous drugs on serum uric acid and urine uric acid excretion
title_sort effect of antituberculous drugs on serum uric acid and urine uric acid excretion
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942518163&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44543
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