Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students

Background: Currently it is believed that human papillomaviruses (HPV) are associated with the development of some oral/oropharyngeal cancers. It has been suggested that these viruses influence carcinogenesis in both smokers and non-smokers. Data on the prevalence of HPV in healthy adults are thus n...

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Main Authors: Yuniardini Septorini Wimardhani, Harum Sasanti, Indriasti Indah Wardhany, Afi Savitri Sarsito, Siti Aliyah Pradono, Gus Permana Subita, Anandina Irmagita Soegyanto, Febrina Rahmayanti, Nutchapon Chamusri, Anak Iamaroon
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/44623
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-446232018-04-25T07:53:50Z Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students Yuniardini Septorini Wimardhani Harum Sasanti Indriasti Indah Wardhany Afi Savitri Sarsito Siti Aliyah Pradono Gus Permana Subita Anandina Irmagita Soegyanto Febrina Rahmayanti Nutchapon Chamusri Anak Iamaroon Agricultural and Biological Sciences Background: Currently it is believed that human papillomaviruses (HPV) are associated with the development of some oral/oropharyngeal cancers. It has been suggested that these viruses influence carcinogenesis in both smokers and non-smokers. Data on the prevalence of HPV in healthy adults are thus needed to estimate the risk of oral/oropharyngeal cancer. The aim of this study was to assess the prevalence of oral HPV in healthy female adults in Indonesia and Thailand. Materials and Methods: Healthy female students from the Faculties of Dentistry of Universitas Indonesia and Chiang Mai University were asked to participate in this pilot study. DNA was extracted from saliva specimens and screened for HPV16 and HPV18 using PCR. Results: The age, marital status and sexual experience of the subjects between the two countries were not significantly different. Eight (4%) and 4 (2%) samples were positive for HPV16 and HPV18, respectively. Fisher's Exact test found a significant difference between HPV16 positivity in subjects who were married and had sexual intercourse but not for HPV18. Conclusions: This study successfully detected presence of HPV16 and HPV18 DNA in a number of saliva samples from female dental school students. Marital status, experience of sexual intercourse and safe sexual practice are related to the possibility of finding HPV DNA finding in saliva. Dentists, physicians and other health care professionals may gain significant value from the findings of this study, which provide an understanding of the nature of HPV infection and its risk to patient health and disease. 2018-01-24T04:45:42Z 2018-01-24T04:45:42Z 2015-01-01 Journal 15137368 2-s2.0-84939440200 10.7314/APJCP.2015.16.13.5525 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939440200&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44623
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Yuniardini Septorini Wimardhani
Harum Sasanti
Indriasti Indah Wardhany
Afi Savitri Sarsito
Siti Aliyah Pradono
Gus Permana Subita
Anandina Irmagita Soegyanto
Febrina Rahmayanti
Nutchapon Chamusri
Anak Iamaroon
Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students
description Background: Currently it is believed that human papillomaviruses (HPV) are associated with the development of some oral/oropharyngeal cancers. It has been suggested that these viruses influence carcinogenesis in both smokers and non-smokers. Data on the prevalence of HPV in healthy adults are thus needed to estimate the risk of oral/oropharyngeal cancer. The aim of this study was to assess the prevalence of oral HPV in healthy female adults in Indonesia and Thailand. Materials and Methods: Healthy female students from the Faculties of Dentistry of Universitas Indonesia and Chiang Mai University were asked to participate in this pilot study. DNA was extracted from saliva specimens and screened for HPV16 and HPV18 using PCR. Results: The age, marital status and sexual experience of the subjects between the two countries were not significantly different. Eight (4%) and 4 (2%) samples were positive for HPV16 and HPV18, respectively. Fisher's Exact test found a significant difference between HPV16 positivity in subjects who were married and had sexual intercourse but not for HPV18. Conclusions: This study successfully detected presence of HPV16 and HPV18 DNA in a number of saliva samples from female dental school students. Marital status, experience of sexual intercourse and safe sexual practice are related to the possibility of finding HPV DNA finding in saliva. Dentists, physicians and other health care professionals may gain significant value from the findings of this study, which provide an understanding of the nature of HPV infection and its risk to patient health and disease.
format Journal
author Yuniardini Septorini Wimardhani
Harum Sasanti
Indriasti Indah Wardhany
Afi Savitri Sarsito
Siti Aliyah Pradono
Gus Permana Subita
Anandina Irmagita Soegyanto
Febrina Rahmayanti
Nutchapon Chamusri
Anak Iamaroon
author_facet Yuniardini Septorini Wimardhani
Harum Sasanti
Indriasti Indah Wardhany
Afi Savitri Sarsito
Siti Aliyah Pradono
Gus Permana Subita
Anandina Irmagita Soegyanto
Febrina Rahmayanti
Nutchapon Chamusri
Anak Iamaroon
author_sort Yuniardini Septorini Wimardhani
title Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students
title_short Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students
title_full Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students
title_fullStr Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students
title_full_unstemmed Saliva-based screening of high-risk human papillomavirus strains: Detection in female Indonesian and Thai dental students
title_sort saliva-based screening of high-risk human papillomavirus strains: detection in female indonesian and thai dental students
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939440200&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44623
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