Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair

Thirty client-owned Pomeranians, between one and seven years old that had grade-three medial patellar luxation, were enrolled in this experiment. The dogs did not have other diseases. All the dogs received the same physical and clinical orthopaedic examinations, as well as the peak vertical force ga...

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Main Authors: Sararat Kongwut, Kumpanart Soontornvipart, Meena Sarikaphuti, Pussadee Makoom, Korakot Nganvongpanit
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/44695
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-446952018-04-25T07:54:42Z Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair Sararat Kongwut Kumpanart Soontornvipart Meena Sarikaphuti Pussadee Makoom Korakot Nganvongpanit Agricultural and Biological Sciences Thirty client-owned Pomeranians, between one and seven years old that had grade-three medial patellar luxation, were enrolled in this experiment. The dogs did not have other diseases. All the dogs received the same physical and clinical orthopaedic examinations, as well as the peak vertical force gait analysis, radiographic examination for assessment of bone deformities. Then, blood was collected from each dog for evaluation of complete blood counts (CBCs), blood chemistry and biomarker assays (IL-1β) before surgery. After surgery to correct their medial patellar luxations, they were divided into three groups by random sampling. The first group received only Firocoxib (5 mg/kg once daily). The second group received only PCSO-524 (10 mg/kg, twice daily). The third group received Firocoxib (5 mg/kg, once daily) combined with PCSO-524 (10 mg/kg, twice daily). Treatment finished at the end of the second week. Every dog received a blood collection before surgery and at days one, five and 14 after surgery. IL-1β concentrations in serum were determined by commercially available canine ELISA kits. The result was that two treatments (Firocoxib only and Firocoxib combined with PCSO-524) can reduce the serum IL-1β level by day 14 after the surgical correction of patellar luxation. However, the group that received PCSO-524 did not have significantly decreased of serum IL-1β, but it had a slower decline of the serum IL-1β level. We concluded that PCSO-524 did not diminish serum IL-1β levels as good as NSAID in case of post-surgical correction of patellar luxation. For the further study, we recommend to increase dose of PCSO-524 and period of treatment before surgery in other condition that causes acute inflammation. Maybe the extraction of active ingredients in PCSO-524 is necessary. Moreover, we suggest increasing the sample size for showing the more significance and accurate results. 2018-01-24T04:46:44Z 2018-01-24T04:46:44Z 2015-01-01 Journal 01256491 2-s2.0-84995663214 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995663214&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44695
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Sararat Kongwut
Kumpanart Soontornvipart
Meena Sarikaphuti
Pussadee Makoom
Korakot Nganvongpanit
Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair
description Thirty client-owned Pomeranians, between one and seven years old that had grade-three medial patellar luxation, were enrolled in this experiment. The dogs did not have other diseases. All the dogs received the same physical and clinical orthopaedic examinations, as well as the peak vertical force gait analysis, radiographic examination for assessment of bone deformities. Then, blood was collected from each dog for evaluation of complete blood counts (CBCs), blood chemistry and biomarker assays (IL-1β) before surgery. After surgery to correct their medial patellar luxations, they were divided into three groups by random sampling. The first group received only Firocoxib (5 mg/kg once daily). The second group received only PCSO-524 (10 mg/kg, twice daily). The third group received Firocoxib (5 mg/kg, once daily) combined with PCSO-524 (10 mg/kg, twice daily). Treatment finished at the end of the second week. Every dog received a blood collection before surgery and at days one, five and 14 after surgery. IL-1β concentrations in serum were determined by commercially available canine ELISA kits. The result was that two treatments (Firocoxib only and Firocoxib combined with PCSO-524) can reduce the serum IL-1β level by day 14 after the surgical correction of patellar luxation. However, the group that received PCSO-524 did not have significantly decreased of serum IL-1β, but it had a slower decline of the serum IL-1β level. We concluded that PCSO-524 did not diminish serum IL-1β levels as good as NSAID in case of post-surgical correction of patellar luxation. For the further study, we recommend to increase dose of PCSO-524 and period of treatment before surgery in other condition that causes acute inflammation. Maybe the extraction of active ingredients in PCSO-524 is necessary. Moreover, we suggest increasing the sample size for showing the more significance and accurate results.
format Journal
author Sararat Kongwut
Kumpanart Soontornvipart
Meena Sarikaphuti
Pussadee Makoom
Korakot Nganvongpanit
author_facet Sararat Kongwut
Kumpanart Soontornvipart
Meena Sarikaphuti
Pussadee Makoom
Korakot Nganvongpanit
author_sort Sararat Kongwut
title Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair
title_short Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair
title_full Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair
title_fullStr Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair
title_full_unstemmed Effect of serum IL-1beta of PCSO-524 and firocoxib in dogs undergoing medial patellar luxation repair
title_sort effect of serum il-1beta of pcso-524 and firocoxib in dogs undergoing medial patellar luxation repair
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995663214&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44695
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