5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics
© 2015 Chiang Mai University. All rights reserved. Sesamin is the primary compound in sesame seed oil which has been used in ayurvedic treatment for hair loss and canities. Sesamin was isolated, identified and investigated for antioxidative activities (including DPPH radical scavenging, lipid peroxi...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934754849&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44716 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-44716 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-447162018-04-25T07:54:57Z 5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics Jiradej Manosroi Pensak Jantrawut Worapaka Manosroi Prachya Kongtawelert Aranya Manosroi Agricultural and Biological Sciences © 2015 Chiang Mai University. All rights reserved. Sesamin is the primary compound in sesame seed oil which has been used in ayurvedic treatment for hair loss and canities. Sesamin was isolated, identified and investigated for antioxidative activities (including DPPH radical scavenging, lipid peroxidation inhibition and metal ion chelating activities), 5α-reductase inhibition in DU-145 and melanogenesis activities on B16F10 melanoma. Sesamin at the concentration of 0.001-10 mg/ml showed weak DPPH scavenging activity (the SC < inf > 50 < /inf > value of 109.90 ± 6.16 mg/ml), but quite high lipid peroxidation inhibition and metal ion chelating activities (the IPC < inf > 50 < /inf > value of 0.83 ± 0.54 and the CC < inf > 50 < /inf > value of 1.83 ± 0.90 mg/ml, respectively). At 0.1 mg/ml of sesamin demonstrated high 5α-reductase inhibition activity at 37.38±4.26% of the control, which was higher than the standard finasteride of 1.54 times, but lower than the standard dutasteride of 1.27 times. It gave high melanin and tyrosinase contents of 26.63±3.21 and 39.42±8.30%, respectively, but lower than theophylline of about 1.04 and 1.05 times, respectively. Although sesamin exhibited all investigated activities lower than the standards, the traditional use of sesame seeds containing sesamin for hair cosmetics has been confirmed, which will be beneficial for the further development as anti-hair loss and anti-canities products. 2018-01-24T04:47:00Z 2018-01-24T04:47:00Z 2015-01-01 Journal 01252526 2-s2.0-84934754849 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934754849&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44716 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Agricultural and Biological Sciences |
spellingShingle |
Agricultural and Biological Sciences Jiradej Manosroi Pensak Jantrawut Worapaka Manosroi Prachya Kongtawelert Aranya Manosroi 5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
description |
© 2015 Chiang Mai University. All rights reserved. Sesamin is the primary compound in sesame seed oil which has been used in ayurvedic treatment for hair loss and canities. Sesamin was isolated, identified and investigated for antioxidative activities (including DPPH radical scavenging, lipid peroxidation inhibition and metal ion chelating activities), 5α-reductase inhibition in DU-145 and melanogenesis activities on B16F10 melanoma. Sesamin at the concentration of 0.001-10 mg/ml showed weak DPPH scavenging activity (the SC < inf > 50 < /inf > value of 109.90 ± 6.16 mg/ml), but quite high lipid peroxidation inhibition and metal ion chelating activities (the IPC < inf > 50 < /inf > value of 0.83 ± 0.54 and the CC < inf > 50 < /inf > value of 1.83 ± 0.90 mg/ml, respectively). At 0.1 mg/ml of sesamin demonstrated high 5α-reductase inhibition activity at 37.38±4.26% of the control, which was higher than the standard finasteride of 1.54 times, but lower than the standard dutasteride of 1.27 times. It gave high melanin and tyrosinase contents of 26.63±3.21 and 39.42±8.30%, respectively, but lower than theophylline of about 1.04 and 1.05 times, respectively. Although sesamin exhibited all investigated activities lower than the standards, the traditional use of sesame seeds containing sesamin for hair cosmetics has been confirmed, which will be beneficial for the further development as anti-hair loss and anti-canities products. |
format |
Journal |
author |
Jiradej Manosroi Pensak Jantrawut Worapaka Manosroi Prachya Kongtawelert Aranya Manosroi |
author_facet |
Jiradej Manosroi Pensak Jantrawut Worapaka Manosroi Prachya Kongtawelert Aranya Manosroi |
author_sort |
Jiradej Manosroi |
title |
5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
title_short |
5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
title_full |
5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
title_fullStr |
5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
title_full_unstemmed |
5α-Reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
title_sort |
5α-reductase inhibition and melanogenesis activity of sesamin from sesame seeds for hair cosmetics |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934754849&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44716 |
_version_ |
1681422611014221824 |