Development of highly stable and low toxic cationic liposomes for gene therapy

• Main Authors: Manosroi A., Thathang K., Werner R.G., Schubert R., Peschka-Suss R., Manosroi J.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-55949118239&partnerID=40&md5=fc18421be2b18b821698b9d68cf01c6c; http://www.ncbi.nlm.nih.gov/pubmed/19025056; http://cmuir.cmu.ac.th/handle/6653943832/4472
• Institution: Chiang Mai University

Cationic liposomes with high stability and low cytotoxicity for gene therapy have been developed. Luciferase plasmid DNA (pLuc) was used as a model gene. The empty liposomes and niosomes were prepared by freeze dried empty liposomes (FDEL) method. The entrapment of pLuc in the liposomes was by recon...