Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion

Solid dispersions of ofloxacin (OFX) and of a number of carriers including chitosan and the water soluble polymers polyethylene glycol (PEG) 4000, PEG 20000, and polyvinylpyrrolidone K-90 were prepared by solvent evaporation method in order to increase the dissolution of the drug. The solid dispersi...

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Main Authors: Okonogi S., Sirithunyalung J., Sirithunyalig B., Wolschann P., Viernstein H.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201885&partnerID=40&md5=85846abe5f86259c07e9b0128244bbee
http://cmuir.cmu.ac.th/handle/6653943832/4475
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-44752014-08-30T02:42:27Z Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion Okonogi S. Sirithunyalung J. Sirithunyalig B. Wolschann P. Viernstein H. Solid dispersions of ofloxacin (OFX) and of a number of carriers including chitosan and the water soluble polymers polyethylene glycol (PEG) 4000, PEG 20000, and polyvinylpyrrolidone K-90 were prepared by solvent evaporation method in order to increase the dissolution of the drug. The solid dispersions were subjected to X-ray diffraction, DSC, and dissolution to characterize their physicochemieal and dissolution properties. The results demonstrated a decrease in drug crystallinity at higher amounts of carrier. Dissolution studies indicated that the dissolution rate of OFX was markedly increased in these solid dispersion systems compared with the pure drug. The results also showed that the increase in dissolution rate was higher when the weight fraction of carriers increased. An influence of molecular weight of PEG on OFX dissolution could also be observed. In solid dispersion with 1:9 ratio drug to carrier, PEG 4000 gave highest drug dissolution rate, whereas in 1:1 ratio, chitosan seems to be the best carrier for drug release. It was concluded that chitosan might be the carrier of choice for dissolution enhancement in solid dispersions with high content of drug. 2014-08-30T02:42:27Z 2014-08-30T02:42:27Z 2002 Article 00368709 SCPHA http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201885&partnerID=40&md5=85846abe5f86259c07e9b0128244bbee http://cmuir.cmu.ac.th/handle/6653943832/4475 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Solid dispersions of ofloxacin (OFX) and of a number of carriers including chitosan and the water soluble polymers polyethylene glycol (PEG) 4000, PEG 20000, and polyvinylpyrrolidone K-90 were prepared by solvent evaporation method in order to increase the dissolution of the drug. The solid dispersions were subjected to X-ray diffraction, DSC, and dissolution to characterize their physicochemieal and dissolution properties. The results demonstrated a decrease in drug crystallinity at higher amounts of carrier. Dissolution studies indicated that the dissolution rate of OFX was markedly increased in these solid dispersion systems compared with the pure drug. The results also showed that the increase in dissolution rate was higher when the weight fraction of carriers increased. An influence of molecular weight of PEG on OFX dissolution could also be observed. In solid dispersion with 1:9 ratio drug to carrier, PEG 4000 gave highest drug dissolution rate, whereas in 1:1 ratio, chitosan seems to be the best carrier for drug release. It was concluded that chitosan might be the carrier of choice for dissolution enhancement in solid dispersions with high content of drug.
format Article
author Okonogi S.
Sirithunyalung J.
Sirithunyalig B.
Wolschann P.
Viernstein H.
spellingShingle Okonogi S.
Sirithunyalung J.
Sirithunyalig B.
Wolschann P.
Viernstein H.
Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
author_facet Okonogi S.
Sirithunyalung J.
Sirithunyalig B.
Wolschann P.
Viernstein H.
author_sort Okonogi S.
title Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
title_short Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
title_full Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
title_fullStr Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
title_full_unstemmed Effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
title_sort effect of carrier types on the physicochemical and dissolution characteristics of ofloxacin solid dispersion
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201885&partnerID=40&md5=85846abe5f86259c07e9b0128244bbee
http://cmuir.cmu.ac.th/handle/6653943832/4475
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