Novel combination therapy to target heart and kidney

© Springer International Publishing Switzerland 2015. Due to a significant burden of the common coexistence of chronic kidney disease (CKD) and cardiovascular disease (CVD) as well as their complex pathophysiological interplay, the concept of integrated cardiorenal pathology has been increasingly re...

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Main Authors: S. Lekawanvijit, H. Krum
Format: Book
Published: 2018
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942530100&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44779
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-447792018-04-25T07:56:24Z Novel combination therapy to target heart and kidney S. Lekawanvijit H. Krum S. Lekawanvijit Agricultural and Biological Sciences © Springer International Publishing Switzerland 2015. Due to a significant burden of the common coexistence of chronic kidney disease (CKD) and cardiovascular disease (CVD) as well as their complex pathophysiological interplay, the concept of integrated cardiorenal pathology has been increasingly recognized. A continuing increase in prevalence of CKD has become a global health concern. One of the major consequences of the growing CKD population is a further deterioration of the CVD epidemic. CKD patients are at extraordinarily high risk for CVD; and CVD in turn is the single most common cause of death in the CKD population, especially in the dialysis-dependent subgroup. Interestingly, traditional cardiovascular risk factors are not sufficient to explain the high prevalence of CVD in this population. There have thus been major efforts in search of novel risk factors specific or closely-related to the CKD milieu. Evidence of non-dialyzable protein-bound uremic toxins as potential risk factors for CKD-associated cardiovascular pathology and mortality as well as potential strategies targeting these toxins has emerged in recent years. At present, indoxyl sulfate and p-cresyl sulfate are the two most problematic toxins with regard to their negative cardiorenal impact. Along with ongoing development in dialysis technique to improve removal of these toxins, novel therapies that reduce the production of such toxins offer a potential approach to alleviating, or even preventing, their toxic effects on heart and kidney. 2018-01-24T04:47:54Z 2018-01-24T04:47:54Z 2015-01-01 Book 2-s2.0-84942530100 10.1007/978-3-319-09162-4_19 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942530100&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44779
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
S. Lekawanvijit
H. Krum
S. Lekawanvijit
Novel combination therapy to target heart and kidney
description © Springer International Publishing Switzerland 2015. Due to a significant burden of the common coexistence of chronic kidney disease (CKD) and cardiovascular disease (CVD) as well as their complex pathophysiological interplay, the concept of integrated cardiorenal pathology has been increasingly recognized. A continuing increase in prevalence of CKD has become a global health concern. One of the major consequences of the growing CKD population is a further deterioration of the CVD epidemic. CKD patients are at extraordinarily high risk for CVD; and CVD in turn is the single most common cause of death in the CKD population, especially in the dialysis-dependent subgroup. Interestingly, traditional cardiovascular risk factors are not sufficient to explain the high prevalence of CVD in this population. There have thus been major efforts in search of novel risk factors specific or closely-related to the CKD milieu. Evidence of non-dialyzable protein-bound uremic toxins as potential risk factors for CKD-associated cardiovascular pathology and mortality as well as potential strategies targeting these toxins has emerged in recent years. At present, indoxyl sulfate and p-cresyl sulfate are the two most problematic toxins with regard to their negative cardiorenal impact. Along with ongoing development in dialysis technique to improve removal of these toxins, novel therapies that reduce the production of such toxins offer a potential approach to alleviating, or even preventing, their toxic effects on heart and kidney.
format Book
author S. Lekawanvijit
H. Krum
S. Lekawanvijit
author_facet S. Lekawanvijit
H. Krum
S. Lekawanvijit
author_sort S. Lekawanvijit
title Novel combination therapy to target heart and kidney
title_short Novel combination therapy to target heart and kidney
title_full Novel combination therapy to target heart and kidney
title_fullStr Novel combination therapy to target heart and kidney
title_full_unstemmed Novel combination therapy to target heart and kidney
title_sort novel combination therapy to target heart and kidney
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942530100&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44779
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