Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum

Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum

One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated comp...

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Main Authors: Atchara Jaidee, Thanika Promchai, Kongkiat Trisuwan, Surat Laphookhieo, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Stephen G. Pyne, Thunwadee Ritthiwigrom
Format: Journal
Published: 2018
Subjects:
Agricultural and Biological Sciences
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946913030&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44872
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-448722018-04-25T07:57:18Z Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum Atchara Jaidee Thanika Promchai Kongkiat Trisuwan Surat Laphookhieo Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Ritthiwigrom Agricultural and Biological Sciences One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC 50 values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity. 2018-01-24T04:49:16Z 2018-01-24T04:49:16Z 2015-01-01 Journal 15559475 1934578X 2-s2.0-84946913030 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946913030&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44872
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Atchara Jaidee
Thanika Promchai
Kongkiat Trisuwan
Surat Laphookhieo
Roonglawan Rattanajak
Sumalee Kamchonwongpaisan
Stephen G. Pyne
Thunwadee Ritthiwigrom
Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
description One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC 50 values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.
format Journal
author Atchara Jaidee
Thanika Promchai
Kongkiat Trisuwan
Surat Laphookhieo
Roonglawan Rattanajak
Sumalee Kamchonwongpaisan
Stephen G. Pyne
Thunwadee Ritthiwigrom
author_facet Atchara Jaidee
Thanika Promchai
Kongkiat Trisuwan
Surat Laphookhieo
Roonglawan Rattanajak
Sumalee Kamchonwongpaisan
Stephen G. Pyne
Thunwadee Ritthiwigrom
author_sort Atchara Jaidee
title Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_short Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_full Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_fullStr Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_full_unstemmed Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_sort cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946913030&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44872
_version_ 1681422640070262784

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