Efavirenz concentrations and probability of HIV replication in children

• Main Authors: Nontiya Homkham, Tim R. Cressey, Naïm Bouazza, Chulapong Chanta, Linda Aurpibul, Thition Narkbunnam, Sawitree Krikajornkitti, Nareerat Kamonpakorn, Marc Lallemant, Lily Ingsrisawang, Nicolas Salvadori, Jean Marc Treluyer, Saik Urien, Gonzague Jourdain
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84944217669&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/44910
• Institution: Chiang Mai University

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load > 400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C12 below target threshold ( < 1.0 mg/L) with a 23% risk of viral replication.