An optimized expression vector for improving the yield of dengue virus-like particles from transfected insect cells

• Main Authors: Nicha Charoensri, Amporn Suphatrakul, Rungtawan Sriburi, Thippawan Yasanga, Jiraphan Junjhon, Poonsook Keelapang, Utaiwan Utaipat, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit, Nopporn Sittisombut
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902001370&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/44982
• Institution: Chiang Mai University

Recombinant virus-like particles (rVLPs) of flaviviruses are non-infectious particles released from cells expressing the envelope glycoproteins prM and E. Dengue virus rVLPs are recognized as a potential vaccine candidate, but large scale production of these particles is hindered by low yields and t...