Amido-3-hydroxypyridin-4-ones as iron(III) ligands

• Main Authors: Piyamongkol S., Ma Y.M., Kong X.L., Liu Z.D., Aytemir M.D., Van Der Helm D., Hider R.C.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952734302&partnerID=40&md5=e8c1e82fec880264e8bf1f28d9e2e374; http://www.ncbi.nlm.nih.gov/pubmed/20397153; http://cmuir.cmu.ac.th/handle/6653943832/4500
• 機構: Chiang Mai University

The synthesis and physicochemical properties of a range of 2and 6-amido-3-hydroxypyridin-4-ones are described. All the amido-substituted 3-hydroxypyridin-4-ones have lower pK a values than 1,2-dimethyl-3-hydr-oxypyridin-4-one (deferiprone). This is due to the inductive effec...