Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin

Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared...

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Main Authors: Kiattikhun Manokruang, Jae Seung Lym, Doo Sung Lee
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897395106&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45043
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-450432018-01-24T06:04:31Z Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin Kiattikhun Manokruang Jae Seung Lym Doo Sung Lee Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. © 2014 Elsevier B.V. 2018-01-24T06:04:31Z 2018-01-24T06:04:31Z 2014-06-01 Journal 0167577X 2-s2.0-84897395106 10.1016/j.matlet.2014.03.052 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897395106&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45043
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. © 2014 Elsevier B.V.
format Journal
author Kiattikhun Manokruang
Jae Seung Lym
Doo Sung Lee
spellingShingle Kiattikhun Manokruang
Jae Seung Lym
Doo Sung Lee
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
author_facet Kiattikhun Manokruang
Jae Seung Lym
Doo Sung Lee
author_sort Kiattikhun Manokruang
title Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_short Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_full Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_fullStr Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_full_unstemmed Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_sort injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897395106&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45043
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