Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line

Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However,...

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Main Authors: Yodkeeree S., Ampasavate C., Sung B., Aggarwal B.B., Limtrakul P.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-73449138207&partnerID=40&md5=eef2dfb40d8371e7da44d7ee359b750c
http://www.ncbi.nlm.nih.gov/pubmed/19818349
http://cmuir.cmu.ac.th/handle/6653943832/4508
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spelling th-cmuir.6653943832-45082014-08-30T02:42:31Z Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line Yodkeeree S. Ampasavate C. Sung B. Aggarwal B.B. Limtrakul P. Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However, the molecular mechanism by which DMC has anti-metastasis activity in breast cancer cells remains poorly understood. Here, we report for the first time that DMC inhibited adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. For cancer cell migration and invasion, extracellular matrix (ECM) degradation processes are required. MDA-MB-231 cells treated with DMC had decreased levels of ECM degradation-associated proteins including matrix metalloproteinase-9 (MMP-9), membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase plasminogen activator (uPA) and uPA receptor (uPAR), while the level of uPA inhibitor (PAI-1) was up-regulated. Moreover, DMC also reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and chemokine receptor 4, (CXCR4), which is involved in modulation of the tumor metastasis process. We also found that DMC treatment inhibited the DNA binding activity of nuclear factor-kappa B (NF-κB), which is known to mediate the expression of MMPs, uPA, uPAR, ICAM-1, and CXCR4. These findings strongly suggest that the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-κB in MDA-MB-231 cells. © 2009 Elsevier B.V. All rights reserved. 2014-08-30T02:42:31Z 2014-08-30T02:42:31Z 2010 Article 142999 10.1016/j.ejphar.2009.09.052 19818349 EJPHA http://www.scopus.com/inward/record.url?eid=2-s2.0-73449138207&partnerID=40&md5=eef2dfb40d8371e7da44d7ee359b750c http://www.ncbi.nlm.nih.gov/pubmed/19818349 http://cmuir.cmu.ac.th/handle/6653943832/4508 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However, the molecular mechanism by which DMC has anti-metastasis activity in breast cancer cells remains poorly understood. Here, we report for the first time that DMC inhibited adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. For cancer cell migration and invasion, extracellular matrix (ECM) degradation processes are required. MDA-MB-231 cells treated with DMC had decreased levels of ECM degradation-associated proteins including matrix metalloproteinase-9 (MMP-9), membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase plasminogen activator (uPA) and uPA receptor (uPAR), while the level of uPA inhibitor (PAI-1) was up-regulated. Moreover, DMC also reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and chemokine receptor 4, (CXCR4), which is involved in modulation of the tumor metastasis process. We also found that DMC treatment inhibited the DNA binding activity of nuclear factor-kappa B (NF-κB), which is known to mediate the expression of MMPs, uPA, uPAR, ICAM-1, and CXCR4. These findings strongly suggest that the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-κB in MDA-MB-231 cells. © 2009 Elsevier B.V. All rights reserved.
format Article
author Yodkeeree S.
Ampasavate C.
Sung B.
Aggarwal B.B.
Limtrakul P.
spellingShingle Yodkeeree S.
Ampasavate C.
Sung B.
Aggarwal B.B.
Limtrakul P.
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
author_facet Yodkeeree S.
Ampasavate C.
Sung B.
Aggarwal B.B.
Limtrakul P.
author_sort Yodkeeree S.
title Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
title_short Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
title_full Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
title_fullStr Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
title_full_unstemmed Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
title_sort demethoxycurcumin suppresses migration and invasion of mda-mb-231 human breast cancer cell line
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-73449138207&partnerID=40&md5=eef2dfb40d8371e7da44d7ee359b750c
http://www.ncbi.nlm.nih.gov/pubmed/19818349
http://cmuir.cmu.ac.th/handle/6653943832/4508
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