Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation

Objective: The objective of this article is to evaluate the efficacy of the first trimester sonomarkers (11-14weeks) in predicting hemoglobin (Hb) Bart's disease among fetuses at risk Materials and Methods: Prospective analysis was conducted on pregnancies at risk of fetal Hb Bart's diseas...

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Main Authors: Supatra Sirichotiyakul, Suchaya Luewan, Kasemsri Srisupundit, Fuanglada Tongprasert, Theera Tongsong
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896722739&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45134
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-451342018-01-24T06:05:48Z Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation Supatra Sirichotiyakul Suchaya Luewan Kasemsri Srisupundit Fuanglada Tongprasert Theera Tongsong Objective: The objective of this article is to evaluate the efficacy of the first trimester sonomarkers (11-14weeks) in predicting hemoglobin (Hb) Bart's disease among fetuses at risk Materials and Methods: Prospective analysis was conducted on pregnancies at risk of fetal Hb Bart's disease at 11 to 14weeks of gestation. Sonographic markers including cardiothoracic (CT) ratio, peak systolic velocity of the middle cerebral artery (MCA-PSV), placental thickness, and nuchal translucency were prospectively assessed and recorded. The definite diagnosis of fetal Hb Bart's disease was based on DNA analysis (chorionic villus sampling) or subsequent fetal Hb typing (high-performance liquid chromatography; cordocentesis). Results: Among 104 pregnancies at risk with complete sonographic assessment at 11 to 14weeks of gestation, 30 fetuses were finally proven to be affected. The CT ratio gave the highest sensitivity, 93.3%, with specificity of 93.2%, followed by placental thickness and MCA-PSV, respectively. Nuchal translucency had a very low sensitivity of 16.7%. The combination of CT ratio and MCA-PSV increased the sensitivity to 96.7% but somewhat compromise specificity. Conclusions: At 11 to 14weeks of gestation, sonographic markers can effectively differentiate affected from unaffected pregnancies. The most sensitive marker was CT ratio plus MCA-PSV. Of couples at risk with no any sonographic markers, the risk of having an affected fetus is nearly eliminated. © 2013 John Wiley & Sons, Ltd. 2018-01-24T06:05:48Z 2018-01-24T06:05:48Z 2014-03-01 Journal 10970223 01973851 2-s2.0-84896722739 10.1002/pd.4293 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896722739&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45134
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Objective: The objective of this article is to evaluate the efficacy of the first trimester sonomarkers (11-14weeks) in predicting hemoglobin (Hb) Bart's disease among fetuses at risk Materials and Methods: Prospective analysis was conducted on pregnancies at risk of fetal Hb Bart's disease at 11 to 14weeks of gestation. Sonographic markers including cardiothoracic (CT) ratio, peak systolic velocity of the middle cerebral artery (MCA-PSV), placental thickness, and nuchal translucency were prospectively assessed and recorded. The definite diagnosis of fetal Hb Bart's disease was based on DNA analysis (chorionic villus sampling) or subsequent fetal Hb typing (high-performance liquid chromatography; cordocentesis). Results: Among 104 pregnancies at risk with complete sonographic assessment at 11 to 14weeks of gestation, 30 fetuses were finally proven to be affected. The CT ratio gave the highest sensitivity, 93.3%, with specificity of 93.2%, followed by placental thickness and MCA-PSV, respectively. Nuchal translucency had a very low sensitivity of 16.7%. The combination of CT ratio and MCA-PSV increased the sensitivity to 96.7% but somewhat compromise specificity. Conclusions: At 11 to 14weeks of gestation, sonographic markers can effectively differentiate affected from unaffected pregnancies. The most sensitive marker was CT ratio plus MCA-PSV. Of couples at risk with no any sonographic markers, the risk of having an affected fetus is nearly eliminated. © 2013 John Wiley & Sons, Ltd.
format Journal
author Supatra Sirichotiyakul
Suchaya Luewan
Kasemsri Srisupundit
Fuanglada Tongprasert
Theera Tongsong
spellingShingle Supatra Sirichotiyakul
Suchaya Luewan
Kasemsri Srisupundit
Fuanglada Tongprasert
Theera Tongsong
Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation
author_facet Supatra Sirichotiyakul
Suchaya Luewan
Kasemsri Srisupundit
Fuanglada Tongprasert
Theera Tongsong
author_sort Supatra Sirichotiyakul
title Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation
title_short Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation
title_full Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation
title_fullStr Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation
title_full_unstemmed Prenatal ultrasound evaluation of fetal Hb Bart's disease among pregnancies at risk at 11 to 14weeks of gestation
title_sort prenatal ultrasound evaluation of fetal hb bart's disease among pregnancies at risk at 11 to 14weeks of gestation
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896722739&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45134
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