Enhanced gentamicin loading and release of PLGA and PLHMGA microspheres by varying the formulation parameters

• Main Authors: Chaisri W., Ghassemi A.H., Hennink W.E., Okonogi S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79952814519&partnerID=40&md5=8d00acb4a07cbf330249fc349fc2f96b; http://www.ncbi.nlm.nih.gov/pubmed/21353499; http://cmuir.cmu.ac.th/handle/6653943832/4517
• Institution: Chiang Mai University

The purpose of this study was to develop a suitable formulation for gentamicin sulfate (GS) that gives a sustained release of the drug. Therefore this drug was loaded into poly(d,l-lactide-co-glycolide) (PLGA) and poly(lactic-co-hydroxymethyl glycolic acid) (PLHMGA) microspheres. The effects of vari...