Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common inherited enzymopathies in endemic areas of malaria including Southeast Asia. The molecular features of G6PD deficiency are similar among Southeast Asian population, with differences in the type of the prominent variants i...

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Main Authors: Pimlak Charoenkwan, Watcharee Tantiprabha, Supatra Sirichotiyakul, Arunee Phusua, Torpong Sanguansermsri
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899499928&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45246
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-452462018-01-24T06:07:17Z Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand Pimlak Charoenkwan Watcharee Tantiprabha Supatra Sirichotiyakul Arunee Phusua Torpong Sanguansermsri Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common inherited enzymopathies in endemic areas of malaria including Southeast Asia. The molecular features of G6PD deficiency are similar among Southeast Asian population, with differences in the type of the prominent variants in each region. This study determined the prevalence and molecular characteristics of G6PD deficiency in northern Thailand. Quantitative assay of G6PD activity was conducted in 566 neonatal cord blood samples and 6 common G6PD mutations were determined by PCR-restriction fragment length polymorphism method on G6PD complete and intermediate deficiency samples. Ninety newborns had G6PD deficiency, with prevalence in male newborns of 17% and that of female newborns having an intermediate and complete deficiency of 13% and 2%, respectively. From 95 G6PD alleles tested, G6PD Mahidol, G6PD Kaiping, G6PD Canton, G6PD Viangchan, G6PD Union, and G6PD Chinese-5 was detected in 19, 17, 15, 13, 7, and 2 alleles, respectively. Our study shows that the prevalence of G6PD deficiency in northern Thai population is high and combination of the common Chinese mutations is the majority, a distribution different from central and southern Thailand where G6PD Viangchan is the prominent variant. These findings suggest a higher proportion of assimilated Chinese ethnic group in the northern Thai population. 2018-01-24T06:07:17Z 2018-01-24T06:07:17Z 2014-01-01 Journal 01251562 2-s2.0-84899499928 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899499928&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45246
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common inherited enzymopathies in endemic areas of malaria including Southeast Asia. The molecular features of G6PD deficiency are similar among Southeast Asian population, with differences in the type of the prominent variants in each region. This study determined the prevalence and molecular characteristics of G6PD deficiency in northern Thailand. Quantitative assay of G6PD activity was conducted in 566 neonatal cord blood samples and 6 common G6PD mutations were determined by PCR-restriction fragment length polymorphism method on G6PD complete and intermediate deficiency samples. Ninety newborns had G6PD deficiency, with prevalence in male newborns of 17% and that of female newborns having an intermediate and complete deficiency of 13% and 2%, respectively. From 95 G6PD alleles tested, G6PD Mahidol, G6PD Kaiping, G6PD Canton, G6PD Viangchan, G6PD Union, and G6PD Chinese-5 was detected in 19, 17, 15, 13, 7, and 2 alleles, respectively. Our study shows that the prevalence of G6PD deficiency in northern Thai population is high and combination of the common Chinese mutations is the majority, a distribution different from central and southern Thailand where G6PD Viangchan is the prominent variant. These findings suggest a higher proportion of assimilated Chinese ethnic group in the northern Thai population.
format Journal
author Pimlak Charoenkwan
Watcharee Tantiprabha
Supatra Sirichotiyakul
Arunee Phusua
Torpong Sanguansermsri
spellingShingle Pimlak Charoenkwan
Watcharee Tantiprabha
Supatra Sirichotiyakul
Arunee Phusua
Torpong Sanguansermsri
Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand
author_facet Pimlak Charoenkwan
Watcharee Tantiprabha
Supatra Sirichotiyakul
Arunee Phusua
Torpong Sanguansermsri
author_sort Pimlak Charoenkwan
title Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand
title_short Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand
title_full Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand
title_fullStr Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand
title_full_unstemmed Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Northern Thailand
title_sort prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in northern thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899499928&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45246
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