Solvent-free reduction of carboxylic acids to alcohols with NaBH<inf>4</inf> promoted by 2,4,6-trichloro-1,3,5-triazine and PPh<inf>3</inf> in the presence of K<inf>2</inf>CO<inf>3</inf>
© the Partner Organisations 2014. A simple, rapid, and eco-friendly method for NaBH 4 reduction of carboxylic acids to alcohols under solvent-free conditions was developed using a combination of 2,4,6-trichloro-1,3,5-triazine (TCT) with a catalytic amount of triphenylphosphine as an acid activator....
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| Main Authors: | , , , , |
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| Format: | Journal |
| Published: |
2018
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| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907647139&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45271 |
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| Institution: | Chiang Mai University |
| Summary: | © the Partner Organisations 2014. A simple, rapid, and eco-friendly method for NaBH 4 reduction of carboxylic acids to alcohols under solvent-free conditions was developed using a combination of 2,4,6-trichloro-1,3,5-triazine (TCT) with a catalytic amount of triphenylphosphine as an acid activator. With the 1 : 0.2 : 1.5 : 2 mole ratio of TCT : PPh 3 : K 2 CO 3 : NaBH 4 , carboxylic acids including aromatic acids, aliphatic acids, and N-protected α-amino acids (Fmoc, Z) could readily undergo reduction to give the corresponding alcohols in good to excellent yields within 10 min. |
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