Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides
Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct r...
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th-cmuir.6653943832-452992018-01-24T06:08:06Z Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides Bannarak Khumraksa Wong Phakhodee Mookda Pattarawarapan Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct reductive amination with amines using sodium borohydride and montmorillonite K-10 catalyst as the reducing system. This green and simple procedure enables N-alkylated amines to be prepared in good to excellent yields with high selectivity of the monoalkylation. This journal is © the Partner Organisations 2014. 2018-01-24T06:08:06Z 2018-01-24T06:08:06Z 2014-01-01 Journal 20462069 2-s2.0-84901257342 10.1039/c4ra02969k https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901257342&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45299 |
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Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct reductive amination with amines using sodium borohydride and montmorillonite K-10 catalyst as the reducing system. This green and simple procedure enables N-alkylated amines to be prepared in good to excellent yields with high selectivity of the monoalkylation. This journal is © the Partner Organisations 2014. |
| format |
Journal |
| author |
Bannarak Khumraksa Wong Phakhodee Mookda Pattarawarapan |
| spellingShingle |
Bannarak Khumraksa Wong Phakhodee Mookda Pattarawarapan Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| author_facet |
Bannarak Khumraksa Wong Phakhodee Mookda Pattarawarapan |
| author_sort |
Bannarak Khumraksa |
| title |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_short |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_full |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_fullStr |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_full_unstemmed |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_sort |
ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| publishDate |
2018 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901257342&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45299 |
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