Designed zinc finger protein interacting with the HIV-1 integrase recognition sequence at 2-LTR-circle junctions

Integration of HIV-1 cDNA into the host genome is a crucial step for viral propagation. Two nucleotides, cytosine and adenine (CA), conserved at the 3′ end of the viral cDNA genome, are cleaved by the viral integrase (IN) enzyme. As IN plays a crucial role in the early stages of the HIV-1 life cycle...

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Bibliographic Details
Main Authors: Sakkhachornphop S., Jiranusornkul S., Kodchakorn K., Nangola S., Sirisanthana T., Tayapiwatana C.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-70350511438&partnerID=40&md5=260ba1b135c3636dfa2b203d92e4f5f0
http://www.ncbi.nlm.nih.gov/pubmed/19701937
http://cmuir.cmu.ac.th/handle/6653943832/4530
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Institution: Chiang Mai University
Language: English
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