Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis

Objective: The purpose of this study was to assess the inferior vena cava (IVC) Doppler changes in fetuses with hydrops fetalis because of anemia, using fetuses with hemoglobin (Hb) Bart's disease as a live model. Methods: Fetuses with hydrops fetalis caused by Hb Bart's disease were measu...

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Main Authors: Suchaya Luewan, Fuanglada Tongprasert, Kasemsri Srisupundit, Theera Tongsong
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901691511&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45305
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-453052018-01-24T06:08:13Z Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis Suchaya Luewan Fuanglada Tongprasert Kasemsri Srisupundit Theera Tongsong Objective: The purpose of this study was to assess the inferior vena cava (IVC) Doppler changes in fetuses with hydrops fetalis because of anemia, using fetuses with hemoglobin (Hb) Bart's disease as a live model. Methods: Fetuses with hydrops fetalis caused by Hb Bart's disease were measured for IVC Doppler indices. The diagnosis of Hb Bart's disease was based on fetal Hb typing. The IVC Doppler indices were compared between the fetuses in early and late hydrops fetalis. Results: Sixty-nine fetuses had satisfactory measurements, 54 in the early group (gestational age < 28weeks) and 15 in the late group (gestational age ≥28weeks). Compared with normal reference ranges, the preload index, peak velocity index, and the pulsatility index were significantly lower in the early group (p < 0.001), whereas they were significantly higher in the late group (p < 0.001). Conclusions: On the basis of evidence of IVC Doppler indices, new insight provided by this study is that in fetal anemia, cardiac decompensation is a consequence of hydrops fetalis, rather than a cause; whereas hypervolemia is the primary cause of hydrops. Additionally, cardiomegaly in most fetuses with high output hydrops fetalis is not a sign of cardiac failure but an effective adaptation to provide oxygen tissue perfusion without increased preload. © 2014 John Wiley & Sons, Ltd. 2018-01-24T06:08:13Z 2018-01-24T06:08:13Z 2014-01-01 Journal 10970223 01973851 2-s2.0-84901691511 10.1002/pd.4351 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901691511&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45305
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Objective: The purpose of this study was to assess the inferior vena cava (IVC) Doppler changes in fetuses with hydrops fetalis because of anemia, using fetuses with hemoglobin (Hb) Bart's disease as a live model. Methods: Fetuses with hydrops fetalis caused by Hb Bart's disease were measured for IVC Doppler indices. The diagnosis of Hb Bart's disease was based on fetal Hb typing. The IVC Doppler indices were compared between the fetuses in early and late hydrops fetalis. Results: Sixty-nine fetuses had satisfactory measurements, 54 in the early group (gestational age < 28weeks) and 15 in the late group (gestational age ≥28weeks). Compared with normal reference ranges, the preload index, peak velocity index, and the pulsatility index were significantly lower in the early group (p < 0.001), whereas they were significantly higher in the late group (p < 0.001). Conclusions: On the basis of evidence of IVC Doppler indices, new insight provided by this study is that in fetal anemia, cardiac decompensation is a consequence of hydrops fetalis, rather than a cause; whereas hypervolemia is the primary cause of hydrops. Additionally, cardiomegaly in most fetuses with high output hydrops fetalis is not a sign of cardiac failure but an effective adaptation to provide oxygen tissue perfusion without increased preload. © 2014 John Wiley & Sons, Ltd.
format Journal
author Suchaya Luewan
Fuanglada Tongprasert
Kasemsri Srisupundit
Theera Tongsong
spellingShingle Suchaya Luewan
Fuanglada Tongprasert
Kasemsri Srisupundit
Theera Tongsong
Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis
author_facet Suchaya Luewan
Fuanglada Tongprasert
Kasemsri Srisupundit
Theera Tongsong
author_sort Suchaya Luewan
title Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis
title_short Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis
title_full Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis
title_fullStr Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis
title_full_unstemmed Inferior vena cava Doppler indices in fetuses with hemoglobin Bart's hydrops fetalis
title_sort inferior vena cava doppler indices in fetuses with hemoglobin bart's hydrops fetalis
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901691511&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45305
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