Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract

© 2014, Chiang Mai University. All rights reserved. Gastric ulcer is a type of gastrointestinal diseases, which affects people all over the world. Modern gastric ulcer drugs have various severe side effects and show less efficacy. Thus, more effective and safer anti-ulcer agents are needed. Reactive...

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Main Authors: Kanokporn Saenphet, Supap Saenphet, Kantarat Jirakittirat
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84936058604&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45347
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spelling th-cmuir.6653943832-453472018-01-24T06:08:52Z Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract Kanokporn Saenphet Supap Saenphet Kantarat Jirakittirat © 2014, Chiang Mai University. All rights reserved. Gastric ulcer is a type of gastrointestinal diseases, which affects people all over the world. Modern gastric ulcer drugs have various severe side effects and show less efficacy. Thus, more effective and safer anti-ulcer agents are needed. Reactive oxygen species have important roles in the pathogenesis of various diseases, including gastric ulcers. The gastroprotective effects and the antioxidant activities of Paederia pilifera Hook.f. (Rubiaceae) root extract were examined on ethanol-induced gastric ulcers in rats. The effects of the plant extract and omeprazole on ulcer index, percentage inhibition, antioxidant activities and lipid peroxidation were evaluated. Antioxidant properties of the plant in vitro were also determined. Root extract of P. pilifera exhibited high total phenolic and ascorbic acid contents and showed free radical scavenging activities. Pretreatment with P. pilifera extract at all doses (250, 500, 750 mg/kg BW) and omeprazole exhibited a significant reduction in gastric mucosal lesions. The percentage inhibition in the rats treated with the extract was dose dependent. Pretreatment with P. pilifera extract and omeprazole showed a significant decrease in lipid peroxidation and an increase in the activities of catalase (CAT) and superoxide dismutase (SOD) enzymes and glutathione (GSH) levels. The cyto-protective and antioxidant properties of the extract found in this study could be due to the presence of the bioactive compounds in extract. 2018-01-24T06:08:52Z 2018-01-24T06:08:52Z 2014-01-01 Journal 01252526 2-s2.0-84936058604 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84936058604&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45347
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2014, Chiang Mai University. All rights reserved. Gastric ulcer is a type of gastrointestinal diseases, which affects people all over the world. Modern gastric ulcer drugs have various severe side effects and show less efficacy. Thus, more effective and safer anti-ulcer agents are needed. Reactive oxygen species have important roles in the pathogenesis of various diseases, including gastric ulcers. The gastroprotective effects and the antioxidant activities of Paederia pilifera Hook.f. (Rubiaceae) root extract were examined on ethanol-induced gastric ulcers in rats. The effects of the plant extract and omeprazole on ulcer index, percentage inhibition, antioxidant activities and lipid peroxidation were evaluated. Antioxidant properties of the plant in vitro were also determined. Root extract of P. pilifera exhibited high total phenolic and ascorbic acid contents and showed free radical scavenging activities. Pretreatment with P. pilifera extract at all doses (250, 500, 750 mg/kg BW) and omeprazole exhibited a significant reduction in gastric mucosal lesions. The percentage inhibition in the rats treated with the extract was dose dependent. Pretreatment with P. pilifera extract and omeprazole showed a significant decrease in lipid peroxidation and an increase in the activities of catalase (CAT) and superoxide dismutase (SOD) enzymes and glutathione (GSH) levels. The cyto-protective and antioxidant properties of the extract found in this study could be due to the presence of the bioactive compounds in extract.
format Journal
author Kanokporn Saenphet
Supap Saenphet
Kantarat Jirakittirat
spellingShingle Kanokporn Saenphet
Supap Saenphet
Kantarat Jirakittirat
Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
author_facet Kanokporn Saenphet
Supap Saenphet
Kantarat Jirakittirat
author_sort Kanokporn Saenphet
title Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
title_short Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
title_full Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
title_fullStr Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
title_full_unstemmed Gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
title_sort gastroprotective effects and antioxidant activities of paederia pilifera hook.f. root extract
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84936058604&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/45347
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