Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)

35% ethanolic extract from Cassia alata Linn. leaves showed antifungal activity against Trigrophyton mentagrophyte, Trigrophyton rubum and Microsporum gypsum. The activity was determined by agar diffusion method. Further purification of 35% ethanolic extract was done by dissolving in methanol and th...

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Main Author: Nantachit K.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-70350051486&partnerID=40&md5=ddaf6b589ecf054d3e1eae581813d889
http://cmuir.cmu.ac.th/handle/6653943832/4552
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-45522014-08-30T02:42:35Z Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae) Nantachit K. 35% ethanolic extract from Cassia alata Linn. leaves showed antifungal activity against Trigrophyton mentagrophyte, Trigrophyton rubum and Microsporum gypsum. The activity was determined by agar diffusion method. Further purification of 35% ethanolic extract was done by dissolving in methanol and the undissolved methanolic material could dissolve in water. This methanolic extract showed antifungal activity against T.mentagrophyte while aqueous extract showed no activity. Isolation and purification of methanolic extract by column chromatography and preparative layer chromatography showed no principal component but consisted of many minor components. These minor components showed antifungal activity against T.mentagrophyte Minimum inhibitory concentration (MIC) of methanolic extract against T.mentagrophyte as determined by agar dilution method was found to be 15 mg/ml. It was also found that 35% ethanolic extract showed less activity against Staphyllococcus aureus ATCC 25923 at 10% W/V concentration. The result from this investigation suggest that ethanolic extract from Cassia alata Linn. leaves can be used for the treatment of ringworm and it is desirable to introduce people to use this plant as in the traditional use. 2014-08-30T02:42:35Z 2014-08-30T02:42:35Z 2009 Article 16851994 http://www.scopus.com/inward/record.url?eid=2-s2.0-70350051486&partnerID=40&md5=ddaf6b589ecf054d3e1eae581813d889 http://cmuir.cmu.ac.th/handle/6653943832/4552 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description 35% ethanolic extract from Cassia alata Linn. leaves showed antifungal activity against Trigrophyton mentagrophyte, Trigrophyton rubum and Microsporum gypsum. The activity was determined by agar diffusion method. Further purification of 35% ethanolic extract was done by dissolving in methanol and the undissolved methanolic material could dissolve in water. This methanolic extract showed antifungal activity against T.mentagrophyte while aqueous extract showed no activity. Isolation and purification of methanolic extract by column chromatography and preparative layer chromatography showed no principal component but consisted of many minor components. These minor components showed antifungal activity against T.mentagrophyte Minimum inhibitory concentration (MIC) of methanolic extract against T.mentagrophyte as determined by agar dilution method was found to be 15 mg/ml. It was also found that 35% ethanolic extract showed less activity against Staphyllococcus aureus ATCC 25923 at 10% W/V concentration. The result from this investigation suggest that ethanolic extract from Cassia alata Linn. leaves can be used for the treatment of ringworm and it is desirable to introduce people to use this plant as in the traditional use.
format Article
author Nantachit K.
spellingShingle Nantachit K.
Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)
author_facet Nantachit K.
author_sort Nantachit K.
title Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)
title_short Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)
title_full Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)
title_fullStr Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)
title_full_unstemmed Antimicrobial activity of Cassia alata Linn. Leaves (caesalpinioideae)
title_sort antimicrobial activity of cassia alata linn. leaves (caesalpinioideae)
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-70350051486&partnerID=40&md5=ddaf6b589ecf054d3e1eae581813d889
http://cmuir.cmu.ac.th/handle/6653943832/4552
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