Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)

From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5- Trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3- Trimethoxy-4,5- dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structu...

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Main Authors:	Wuttikrai Sesang, Sittiporn Punyanitya, Siripit Pitchuanchom, Phansuang Udomputtimekakul, Narong Nuntasaen, Ratana Banjerdpongchai, Benjawan Wudtiwai, Wilart Pompimon
Format:	Journal
Published:	2018
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904787784&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45632
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-456322018-01-24T06:14:14Z Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib) Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5- Trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3- Trimethoxy-4,5- dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC 50 values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC 50 levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively. 2018-01-24T06:14:14Z 2018-01-24T06:14:14Z 2014-01-01 Journal 14203049 2-s2.0-84904787784 10.3390/molecules19078762 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904787784&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45632
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
description	From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5- Trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3- Trimethoxy-4,5- dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC 50 values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC 50 levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively.
format	Journal
author	Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon
spellingShingle	Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
author_facet	Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon
author_sort	Wuttikrai Sesang
title	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_short	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_full	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_fullStr	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_full_unstemmed	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_sort	cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (craib)
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904787784&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/45632
_version_	1681422781640605696

Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)

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