Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]

Background: Duhuo Jisheng Wan (DJW) is perhaps the best known and most widely used Chinese herbal recipe for arthralgia, but the clinical study to verify its efficacy is lacking. The purpose of this study was to compare the efficacy of DJW versus diclofenac in symptomatic treatment of osteoarthritis...

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Main Authors: Teekachunhatean S., Kunanusorn P., Rojanasthien N., Sananpanich K., Pojchamarnwiputh S., Lhieochaiphunt S., Pruksakorn S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-25444481576&partnerID=40&md5=7f67275d4194af6c3d7de6fc58e5971b
http://www.ncbi.nlm.nih.gov/pubmed/15588333
http://cmuir.cmu.ac.th/handle/6653943832/4607
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spelling th-cmuir.6653943832-46072014-08-30T02:42:39Z Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892] Teekachunhatean S. Kunanusorn P. Rojanasthien N. Sananpanich K. Pojchamarnwiputh S. Lhieochaiphunt S. Pruksakorn S. Background: Duhuo Jisheng Wan (DJW) is perhaps the best known and most widely used Chinese herbal recipe for arthralgia, but the clinical study to verify its efficacy is lacking. The purpose of this study was to compare the efficacy of DJW versus diclofenac in symptomatic treatment of osteoarthritis (OA) of the knee. Methods: This study was a randomized, double-blind, double-dummy, controlled trial. The 200 patients suffering from OA of the knee, were randomized into the DJW and diclofenac group. The patients were evaluated after a run-in period of one week (week 0) and then weekly during 4 weeks of treatment. The clinical assessments included visual analog scale (VAS) score that assessed pain and stiffness, Lequesne's functional index, time for climbing up 10 steps, as well as physician's and patients' overall opinions on improvement. Results: Ninety four patients in each group completed the study. In the first few weeks of treatment, the mean changes in some variables (VAS, which assessed walking pain, standing pain and stiffness, as well as Lequesne's functional index) of the DJW group were significantly lower than those of the diclofenac group. Afterwards, these mean changes became no different throughout the study. Most of the physician's and patients' overall opinions on improvement at each time point did not significantly differ between the two groups. Approximately 30% of patients in both groups experienced mild adverse events. Conclusion: DJW demonstrates clinically comparable efficacy to diclofenac after 4 weeks of treatment. However, the slow onset of action as well as approximately equal rate of adverse events to diclofenac might limit its alternative role in treatment of OA of the knee. © 2004 Teekachunhatean et al; licensee BioMed Central Ltd. 2014-08-30T02:42:39Z 2014-08-30T02:42:39Z 2004 Article 14726882 10.1186/1472-6882-4-19 15588333 BCAMC http://www.scopus.com/inward/record.url?eid=2-s2.0-25444481576&partnerID=40&md5=7f67275d4194af6c3d7de6fc58e5971b http://www.ncbi.nlm.nih.gov/pubmed/15588333 http://cmuir.cmu.ac.th/handle/6653943832/4607 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background: Duhuo Jisheng Wan (DJW) is perhaps the best known and most widely used Chinese herbal recipe for arthralgia, but the clinical study to verify its efficacy is lacking. The purpose of this study was to compare the efficacy of DJW versus diclofenac in symptomatic treatment of osteoarthritis (OA) of the knee. Methods: This study was a randomized, double-blind, double-dummy, controlled trial. The 200 patients suffering from OA of the knee, were randomized into the DJW and diclofenac group. The patients were evaluated after a run-in period of one week (week 0) and then weekly during 4 weeks of treatment. The clinical assessments included visual analog scale (VAS) score that assessed pain and stiffness, Lequesne's functional index, time for climbing up 10 steps, as well as physician's and patients' overall opinions on improvement. Results: Ninety four patients in each group completed the study. In the first few weeks of treatment, the mean changes in some variables (VAS, which assessed walking pain, standing pain and stiffness, as well as Lequesne's functional index) of the DJW group were significantly lower than those of the diclofenac group. Afterwards, these mean changes became no different throughout the study. Most of the physician's and patients' overall opinions on improvement at each time point did not significantly differ between the two groups. Approximately 30% of patients in both groups experienced mild adverse events. Conclusion: DJW demonstrates clinically comparable efficacy to diclofenac after 4 weeks of treatment. However, the slow onset of action as well as approximately equal rate of adverse events to diclofenac might limit its alternative role in treatment of OA of the knee. © 2004 Teekachunhatean et al; licensee BioMed Central Ltd.
format Article
author Teekachunhatean S.
Kunanusorn P.
Rojanasthien N.
Sananpanich K.
Pojchamarnwiputh S.
Lhieochaiphunt S.
Pruksakorn S.
spellingShingle Teekachunhatean S.
Kunanusorn P.
Rojanasthien N.
Sananpanich K.
Pojchamarnwiputh S.
Lhieochaiphunt S.
Pruksakorn S.
Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
author_facet Teekachunhatean S.
Kunanusorn P.
Rojanasthien N.
Sananpanich K.
Pojchamarnwiputh S.
Lhieochaiphunt S.
Pruksakorn S.
author_sort Teekachunhatean S.
title Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
title_short Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
title_full Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
title_fullStr Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
title_full_unstemmed Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
title_sort chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [isrctn70292892]
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-25444481576&partnerID=40&md5=7f67275d4194af6c3d7de6fc58e5971b
http://www.ncbi.nlm.nih.gov/pubmed/15588333
http://cmuir.cmu.ac.th/handle/6653943832/4607
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