Decline in CD4 T lymphocytes with monotherapy bridging strategy for non-adherent adolescents living with HIV infection: Results of the IMPAACT P1094 randomized trial

• Main Authors: Allison L. Agwu, Meredith G. Warshaw, Elizabeth J. McFarland, George K. Siberry, Ann J. Melvin, Andrew A. Wiznia, Lee Fairlie, Sandra Boyd, Paul Harding, Hans M.L. Spiegel, Elaine J. Abrams, Vincent J. Carey, Murli Purswani, Linda Aurpibul, Virat Sirisanthana, Chintana Khamrong, Joan Wilson, Margaret Donnelly, John Swetnam, Erica Stankievich, Silvina A. Ivalo, Irene Foradori, Ivete Martins Gomes, Jose Henrique Pilotto, Cintia Lopes Da Silva, Marinella Della Negra, Yu Ching Lian, Denise Peluso Pacola, Thuy C. Anderson, Todd C. Noletto
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020697190&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/46211
• Institution: Chiang Mai University

Introduction: Management of persistently non-adherent youth living with HIV (YLHIV) with virologic failure (VF) on combination antiretroviral therapy (cART) remains challenging. One strategy has been using 3TC/FTC monotherapy (3TC/FTC), which in the presence of the M184V resistance mutation, does no...