Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
© 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE...
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th-cmuir.6653943832-462132018-04-25T07:24:41Z Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus Phatcharaporn Budluang Pornsiri Pitchakarn Pisamai Ting Piya Temviriyanukul Ariyaphong Wongnoppawich Arisa Imsumran Agricultural and Biological Sciences © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose-dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)-treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)-α treated 3T3-L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of A. burmannicus as anti-inflammatory, anti-insulin resistance agents, or food supplement for prevention of chronic diseases. 2018-04-25T06:51:29Z 2018-04-25T06:51:29Z 2017-05-01 Journal 20487177 2-s2.0-84997785114 10.1002/fsn3.416 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84997785114&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46213 |
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Agricultural and Biological Sciences Phatcharaporn Budluang Pornsiri Pitchakarn Pisamai Ting Piya Temviriyanukul Ariyaphong Wongnoppawich Arisa Imsumran Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus |
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© 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose-dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)-treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)-α treated 3T3-L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of A. burmannicus as anti-inflammatory, anti-insulin resistance agents, or food supplement for prevention of chronic diseases. |
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Phatcharaporn Budluang Pornsiri Pitchakarn Pisamai Ting Piya Temviriyanukul Ariyaphong Wongnoppawich Arisa Imsumran |
author_facet |
Phatcharaporn Budluang Pornsiri Pitchakarn Pisamai Ting Piya Temviriyanukul Ariyaphong Wongnoppawich Arisa Imsumran |
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Phatcharaporn Budluang |
title |
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus |
title_short |
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus |
title_full |
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus |
title_fullStr |
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus |
title_full_unstemmed |
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus |
title_sort |
anti-inflammatory and anti-insulin resistance activities of aqueous extract from anoectochilus burmannicus |
publishDate |
2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84997785114&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46213 |
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