Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus

© 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE...

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Main Authors: Phatcharaporn Budluang, Pornsiri Pitchakarn, Pisamai Ting, Piya Temviriyanukul, Ariyaphong Wongnoppawich, Arisa Imsumran
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/46213
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-462132018-04-25T07:24:41Z Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus Phatcharaporn Budluang Pornsiri Pitchakarn Pisamai Ting Piya Temviriyanukul Ariyaphong Wongnoppawich Arisa Imsumran Agricultural and Biological Sciences © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose-dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)-treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)-α treated 3T3-L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of A. burmannicus as anti-inflammatory, anti-insulin resistance agents, or food supplement for prevention of chronic diseases. 2018-04-25T06:51:29Z 2018-04-25T06:51:29Z 2017-05-01 Journal 20487177 2-s2.0-84997785114 10.1002/fsn3.416 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84997785114&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46213
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Phatcharaporn Budluang
Pornsiri Pitchakarn
Pisamai Ting
Piya Temviriyanukul
Ariyaphong Wongnoppawich
Arisa Imsumran
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
description © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose-dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)-treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)-α treated 3T3-L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of A. burmannicus as anti-inflammatory, anti-insulin resistance agents, or food supplement for prevention of chronic diseases.
format Journal
author Phatcharaporn Budluang
Pornsiri Pitchakarn
Pisamai Ting
Piya Temviriyanukul
Ariyaphong Wongnoppawich
Arisa Imsumran
author_facet Phatcharaporn Budluang
Pornsiri Pitchakarn
Pisamai Ting
Piya Temviriyanukul
Ariyaphong Wongnoppawich
Arisa Imsumran
author_sort Phatcharaporn Budluang
title Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
title_short Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
title_full Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
title_fullStr Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
title_full_unstemmed Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
title_sort anti-inflammatory and anti-insulin resistance activities of aqueous extract from anoectochilus burmannicus
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84997785114&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46213
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