Cytotoxicity of extracts from fruit plants against leukemic cell lines

This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leave...

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Main Authors:	Ampasavate C., Okonogi S., Anuchapreeda S.
Format:	Article
Language:	English
Published:	2014
Online Access:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77953654344&partnerID=40&md5=08d884acb4d65333e2e0b4455f45251f http://cmuir.cmu.ac.th/handle/6653943832/4623
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Institution:	Chiang Mai University
Language:	English

id	th-cmuir.6653943832-4623
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spelling	th-cmuir.6653943832-46232014-08-30T02:42:40Z Cytotoxicity of extracts from fruit plants against leukemic cell lines Ampasavate C. Okonogi S. Anuchapreeda S. This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leaves, mangosteen peels, and wampee leaves) had strong cytotoxic effects on K562, U937, and Molt4 cells. The IC50 values of kaffir lime leaves on those cells were 26.1, 9.0 and 11.9 μg/ml respectively, whereas those of mangosteen peel were 23.6, 4.5 and 10.1 μg/ml, and those of wampee leaves were 71.9, 13 and 70.4 μg/ml. Furthermore, pomegranate peel extract had a potent cytotoxic effect on HL60 cells (IC50 of 8.0 μg/ml), but was non-toxic to normal PBMCs, indicating that as a potential source of antileukemic agents. © 2010 Academic Journals. 2014-08-30T02:42:40Z 2014-08-30T02:42:40Z 2010 Article 19960816 http://www.scopus.com/inward/record.url?eid=2-s2.0-77953654344&partnerID=40&md5=08d884acb4d65333e2e0b4455f45251f http://cmuir.cmu.ac.th/handle/6653943832/4623 English
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
language	English
description	This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leaves, mangosteen peels, and wampee leaves) had strong cytotoxic effects on K562, U937, and Molt4 cells. The IC50 values of kaffir lime leaves on those cells were 26.1, 9.0 and 11.9 μg/ml respectively, whereas those of mangosteen peel were 23.6, 4.5 and 10.1 μg/ml, and those of wampee leaves were 71.9, 13 and 70.4 μg/ml. Furthermore, pomegranate peel extract had a potent cytotoxic effect on HL60 cells (IC50 of 8.0 μg/ml), but was non-toxic to normal PBMCs, indicating that as a potential source of antileukemic agents. © 2010 Academic Journals.
format	Article
author	Ampasavate C. Okonogi S. Anuchapreeda S.
spellingShingle	Ampasavate C. Okonogi S. Anuchapreeda S. Cytotoxicity of extracts from fruit plants against leukemic cell lines
author_facet	Ampasavate C. Okonogi S. Anuchapreeda S.
author_sort	Ampasavate C.
title	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_short	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_full	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_fullStr	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_full_unstemmed	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_sort	cytotoxicity of extracts from fruit plants against leukemic cell lines
publishDate	2014
url	http://www.scopus.com/inward/record.url?eid=2-s2.0-77953654344&partnerID=40&md5=08d884acb4d65333e2e0b4455f45251f http://cmuir.cmu.ac.th/handle/6653943832/4623
_version_	1681420271997681664

Cytotoxicity of extracts from fruit plants against leukemic cell lines

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