Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci

© 2017, Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA. All rights reserved. Host microbiome and metabolome are associated with the incidence of colorectal cancer (CC), one of the major health problems in developed countries. The pro and prebiotic supplementation helps to improve t...

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Main Authors: Chaiyavat Chaiyasut, Thanawat Pattananandecha, Sasithorn Sirilun, Prasit Suwannalert, Sartjin Peerajan, Bhagavathi Sundaram Sivamaruthi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/46292
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-462922018-04-25T07:32:32Z Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci Chaiyavat Chaiyasut Thanawat Pattananandecha Sasithorn Sirilun Prasit Suwannalert Sartjin Peerajan Bhagavathi Sundaram Sivamaruthi Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences © 2017, Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA. All rights reserved. Host microbiome and metabolome are associated with the incidence of colorectal cancer (CC), one of the major health problems in developed countries. The pro and prebiotic supplementation helps to improve the host health. Inulin is one such prebiotic used for the enhancement of naïve probiotic bacterial population. This paper explains the impact of inulin (PRE) extracted from Jerusalem artichoke (JA), Lactobacillus plantarum HII11 (PRO), and synbiotic (SYN; inulin + L. plantarum HII11) preparation on Azoxymethane mediated CC induced rat model with respect to changes in microbial load, microbial enzymes, and preneoplastic aberrant crypt foci. The results suggested that the PRE and SYN supplementation effectively reduced the selected pathogenic bacteria (Salmonella spp., and Escherichia coli), microbial enzymes and increased the probiotic load. The intervention of SYN significantly reduced the colonic ACF in CC model. The study results revealed that the supplementation of SYN diet (inulin and L. plantarum HII11) protects the AOM-mediated colon cancer induced host. 2018-04-25T06:52:23Z 2018-04-25T06:52:23Z 2017-01-01 Journal 1678457X 2-s2.0-85020220571 10.1590/1678-457X.26216 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020220571&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46292
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Agricultural and Biological Sciences
spellingShingle Biochemistry, Genetics and Molecular Biology
Agricultural and Biological Sciences
Chaiyavat Chaiyasut
Thanawat Pattananandecha
Sasithorn Sirilun
Prasit Suwannalert
Sartjin Peerajan
Bhagavathi Sundaram Sivamaruthi
Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
description © 2017, Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA. All rights reserved. Host microbiome and metabolome are associated with the incidence of colorectal cancer (CC), one of the major health problems in developed countries. The pro and prebiotic supplementation helps to improve the host health. Inulin is one such prebiotic used for the enhancement of naïve probiotic bacterial population. This paper explains the impact of inulin (PRE) extracted from Jerusalem artichoke (JA), Lactobacillus plantarum HII11 (PRO), and synbiotic (SYN; inulin + L. plantarum HII11) preparation on Azoxymethane mediated CC induced rat model with respect to changes in microbial load, microbial enzymes, and preneoplastic aberrant crypt foci. The results suggested that the PRE and SYN supplementation effectively reduced the selected pathogenic bacteria (Salmonella spp., and Escherichia coli), microbial enzymes and increased the probiotic load. The intervention of SYN significantly reduced the colonic ACF in CC model. The study results revealed that the supplementation of SYN diet (inulin and L. plantarum HII11) protects the AOM-mediated colon cancer induced host.
format Journal
author Chaiyavat Chaiyasut
Thanawat Pattananandecha
Sasithorn Sirilun
Prasit Suwannalert
Sartjin Peerajan
Bhagavathi Sundaram Sivamaruthi
author_facet Chaiyavat Chaiyasut
Thanawat Pattananandecha
Sasithorn Sirilun
Prasit Suwannalert
Sartjin Peerajan
Bhagavathi Sundaram Sivamaruthi
author_sort Chaiyavat Chaiyasut
title Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
title_short Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
title_full Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
title_fullStr Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
title_full_unstemmed Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
title_sort synbiotic preparation with lactic acid bacteria and inulin as a functional food: in vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020220571&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46292
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