A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans

© 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhi...

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Main Authors: Tadayoshi Onozawa, Mariko Kitajima, Noriyuki Kogure, Nichakan Peerakam, Dammrong Santiarworn, Hiromitsu Takayama
Format: Journal
Published: 2018
Subjects:
Chemistry
Agricultural and Biological Sciences
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46367
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-463672018-04-25T07:22:22Z A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans Tadayoshi Onozawa Mariko Kitajima Noriyuki Kogure Nichakan Peerakam Dammrong Santiarworn Hiromitsu Takayama Chemistry Agricultural and Biological Sciences © 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis. 2018-04-25T06:53:52Z 2018-04-25T06:53:52Z 2017-07-28 Journal 15206025 01633864 2-s2.0-85026509664 10.1021/acs.jnatprod.7b00290 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46367
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Chemistry
Agricultural and Biological Sciences
spellingShingle Chemistry
Agricultural and Biological Sciences
Tadayoshi Onozawa
Mariko Kitajima
Noriyuki Kogure
Nichakan Peerakam
Dammrong Santiarworn
Hiromitsu Takayama
A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
description © 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis.
format Journal
author Tadayoshi Onozawa
Mariko Kitajima
Noriyuki Kogure
Nichakan Peerakam
Dammrong Santiarworn
Hiromitsu Takayama
author_facet Tadayoshi Onozawa
Mariko Kitajima
Noriyuki Kogure
Nichakan Peerakam
Dammrong Santiarworn
Hiromitsu Takayama
author_sort Tadayoshi Onozawa
title A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_short A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_full A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_fullStr A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_full_unstemmed A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_sort cyclopeptide and a tetrahydroisoquinoline alkaloid from ophiorrhiza nutans
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46367
_version_ 1681422861253738496

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