Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus

Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus

© 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectrosco...

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Main Authors: Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat Trisuwan
Format: Journal
Published: 2018
Subjects:
Chemistry
Agricultural and Biological Sciences
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46462
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-464622018-04-25T07:32:03Z Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus Sirada Boonyaketgoson Vatcharin Rukachaisirikul Souwalak Phongpaichit Kongkiat Trisuwan Chemistry Agricultural and Biological Sciences © 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC 50 value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC 50 values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively. 2018-04-25T06:55:13Z 2018-04-25T06:55:13Z 2017-01-01 Journal 18733581 00404039 2-s2.0-85015307707 10.1016/j.tetlet.2017.03.020 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46462
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Chemistry
Agricultural and Biological Sciences
spellingShingle Chemistry
Agricultural and Biological Sciences
Sirada Boonyaketgoson
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Kongkiat Trisuwan
Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
description © 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC 50 value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC 50 values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively.
format Journal
author Sirada Boonyaketgoson
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Kongkiat Trisuwan
author_facet Sirada Boonyaketgoson
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Kongkiat Trisuwan
author_sort Sirada Boonyaketgoson
title Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_short Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_full Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_fullStr Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_full_unstemmed Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_sort cytotoxic arylbenzofuran and stilbene derivatives from the twigs of artocarpus heterophyllus
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46462
_version_ 1681422879113084928

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