3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line

• Main Authors: Kikuchi T., Akazawa H., Tabata K., Manosroi A., Manosroi J., Suzuki T., Akihisa T.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79952412542&partnerID=40&md5=080bcb04a6b6a10d5da0e2fa8dcc87c9; http://cmuir.cmu.ac.th/handle/6653943832/4648
• Institution: Chiang Mai University

Eleven triterpene acids, 1-11, isolated from the leaves of Eriobotrya japonica, were evaluated for inhibition of DNA topoisomerase (Topo) I and cytotoxicity against human leukemia (HL60) and melanoma cell lines (CRL1579). Among the compounds tested, four compounds, d-oleanolic acid (4), ursolic acid...