Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

• Main Authors: Franziska Faber, Parameth Thiennimitr, Luisella Spiga, Mariana X. Byndloss, Yael Litvak, Sara Lawhon, Helene L. Andrews-Polymenis, Sebastian E. Winter, Andreas J. Bäumler
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology; Agricultural and Biological Sciences
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85011005490&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/46480
• Institution: Chiang Mai University

© 2017 Faber et al. Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.