Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial

Background: Topical tranexamic acid has been claimed to lighten melasma without serious adverse effects. However, controlled studies assessing the efficacy and safety of topical tranexamic acid (TA) for the treatment of melasma is limited. Objective: To assess in a double blind, randomized, prospect...

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Main Authors: Ayuthaya P.K.N., Niumphradit N., Manosroi A., Nakakes A.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84861083026&partnerID=40&md5=53acb3c97bd7603ad6d264a443e83068
http://cmuir.cmu.ac.th/handle/6653943832/4653
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-46532014-08-30T02:42:42Z Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial Ayuthaya P.K.N. Niumphradit N. Manosroi A. Nakakes A. Background: Topical tranexamic acid has been claimed to lighten melasma without serious adverse effects. However, controlled studies assessing the efficacy and safety of topical tranexamic acid (TA) for the treatment of melasma is limited. Objective: To assess in a double blind, randomized, prospective study, the efficacy of topical 5% tranexamic acid versus vehicle for treatment of melasma. Methods: Twenty-three women with bilateral epidermal melasma enrolled in a split-face trial lasting 12 weeks. Patients blindly applied topical 5% tranexamic acid and its vehicle, to the designated sides of the face twice daily in addition to the assigned sunscreen each morning. Pigmentation and erythema were measured objectively using a mexameter and Melasma Area and Severity Index (MASI), in addition to physician and patient global assessments. Results: Twenty-one patients completed the study. Eighteen out of twenty-three patients (78.2%) showed decrease in the melanin index on either or both sides of the face by the end of 12 weeks compared to baseline. The MASI scores were also significantly reduced on both tested sides. However, lightening of pigmentation induced by TA gel was neither superior nor different (p >0.05) compared to its vehicle although erythema was significant on the TA-applied site (p <0.05). Conclusions: Although lightening of pigmentation was obtained, the results were not significant between the two regimens. However, topical TA produced erythema. © 2012 Informa UK, Ltd. 2014-08-30T02:42:42Z 2014-08-30T02:42:42Z 2012 Article 14764172 10.3109/14764172.2012.685478 22506692 JCLTC http://www.scopus.com/inward/record.url?eid=2-s2.0-84861083026&partnerID=40&md5=53acb3c97bd7603ad6d264a443e83068 http://cmuir.cmu.ac.th/handle/6653943832/4653 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background: Topical tranexamic acid has been claimed to lighten melasma without serious adverse effects. However, controlled studies assessing the efficacy and safety of topical tranexamic acid (TA) for the treatment of melasma is limited. Objective: To assess in a double blind, randomized, prospective study, the efficacy of topical 5% tranexamic acid versus vehicle for treatment of melasma. Methods: Twenty-three women with bilateral epidermal melasma enrolled in a split-face trial lasting 12 weeks. Patients blindly applied topical 5% tranexamic acid and its vehicle, to the designated sides of the face twice daily in addition to the assigned sunscreen each morning. Pigmentation and erythema were measured objectively using a mexameter and Melasma Area and Severity Index (MASI), in addition to physician and patient global assessments. Results: Twenty-one patients completed the study. Eighteen out of twenty-three patients (78.2%) showed decrease in the melanin index on either or both sides of the face by the end of 12 weeks compared to baseline. The MASI scores were also significantly reduced on both tested sides. However, lightening of pigmentation induced by TA gel was neither superior nor different (p >0.05) compared to its vehicle although erythema was significant on the TA-applied site (p <0.05). Conclusions: Although lightening of pigmentation was obtained, the results were not significant between the two regimens. However, topical TA produced erythema. © 2012 Informa UK, Ltd.
format Article
author Ayuthaya P.K.N.
Niumphradit N.
Manosroi A.
Nakakes A.
spellingShingle Ayuthaya P.K.N.
Niumphradit N.
Manosroi A.
Nakakes A.
Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial
author_facet Ayuthaya P.K.N.
Niumphradit N.
Manosroi A.
Nakakes A.
author_sort Ayuthaya P.K.N.
title Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial
title_short Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial
title_full Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial
title_fullStr Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial
title_full_unstemmed Topical 5% tranexamic acid for the treatment of melasma in Asians: A double-blind randomized controlled clinical trial
title_sort topical 5% tranexamic acid for the treatment of melasma in asians: a double-blind randomized controlled clinical trial
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84861083026&partnerID=40&md5=53acb3c97bd7603ad6d264a443e83068
http://cmuir.cmu.ac.th/handle/6653943832/4653
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