Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin

© 2017 by the authors. This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concent...

Full description

Saved in:
Bibliographic Details
Main Authors: Pensak Jantrawut, Tanpong Chaiwarit, Kittisak Jantanasakulwong, Claire Hélène Brachais, Odile Chambin
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85025120053&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46584
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-46584
record_format dspace
spelling th-cmuir.6653943832-465842018-04-25T07:22:30Z Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin Pensak Jantrawut Tanpong Chaiwarit Kittisak Jantanasakulwong Claire Hélène Brachais Odile Chambin Materials Science Agricultural and Biological Sciences © 2017 by the authors. This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20-40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated. Without any plasticizer, a brittle LMP film with low tensile strength and % elongation at break was obtained. Addition of plasticizers from 20% to 40% caused reduction in the tensile strength and Young's modulus values, whereas percent elongation was increased. Forty percent Gly-plasticized and PG-plasticized films were selected to deliver indomethacin in comparison with non-plasticized film. No significant difference in indomethacin release profiles was displayed between the films. The analysis of indomethacin release model indicated that more than one drug release mechanism from the film formulation was involved and possibly the combination of both diffusion and erosion. Even though indomethacin incorporated in non-plasticized film showed similar release profile, Gly or PG should be added to enhanced film flexibility and decrease film brittleness. 2018-04-25T06:57:15Z 2018-04-25T06:57:15Z 2017-07-20 Journal 20734360 2-s2.0-85025120053 10.3390/polym9070289 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85025120053&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/46584
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Materials Science
Agricultural and Biological Sciences
spellingShingle Materials Science
Agricultural and Biological Sciences
Pensak Jantrawut
Tanpong Chaiwarit
Kittisak Jantanasakulwong
Claire Hélène Brachais
Odile Chambin
Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
description © 2017 by the authors. This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20-40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated. Without any plasticizer, a brittle LMP film with low tensile strength and % elongation at break was obtained. Addition of plasticizers from 20% to 40% caused reduction in the tensile strength and Young's modulus values, whereas percent elongation was increased. Forty percent Gly-plasticized and PG-plasticized films were selected to deliver indomethacin in comparison with non-plasticized film. No significant difference in indomethacin release profiles was displayed between the films. The analysis of indomethacin release model indicated that more than one drug release mechanism from the film formulation was involved and possibly the combination of both diffusion and erosion. Even though indomethacin incorporated in non-plasticized film showed similar release profile, Gly or PG should be added to enhanced film flexibility and decrease film brittleness.
format Journal
author Pensak Jantrawut
Tanpong Chaiwarit
Kittisak Jantanasakulwong
Claire Hélène Brachais
Odile Chambin
author_facet Pensak Jantrawut
Tanpong Chaiwarit
Kittisak Jantanasakulwong
Claire Hélène Brachais
Odile Chambin
author_sort Pensak Jantrawut
title Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
title_short Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
title_full Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
title_fullStr Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
title_full_unstemmed Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
title_sort effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85025120053&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46584
_version_ 1681422901710946304