Application of N-Acylbenzotriazoles in the Synthesis of 5-Substituted 2-Ethoxy-1,3,4-oxadiazoles as Building Blocks toward 3,5-Disubstituted 1,3,4-Oxadiazol-2(3H)-ones

• Main Authors: Sirawit Wet-Osot, Wong Phakhodee, Mookda Pattarawarapan
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029484222&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/46606
• Institution: Chiang Mai University

© 2017 American Chemical Society. 5-Substituted-2-ethoxy-1,3,4-oxadiazoles were conveniently prepared through a one-pot sequential N-acylation/dehydrative cyclization between ethyl carbazate and N-acylbenzotriazoles in the presence of Ph 3 P-I 2 as a dehydrating agent. Subsequent treatment with a st...