Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists
© 2017, Medical Association of Thailand. All rights reserved. Objective: The present study intended to determine the risk factors of severe exacerbation in chronic obstructive pulmonary disease patients even though managed by pulmonologists on a regular basis. Material and Method: A retrospective ca...
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th-cmuir.6653943832-472422018-04-25T07:27:37Z Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists Chaicharn Pothirat Thatawan Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Athavudh Deesomchok Theerakorn Theerakittikul Atikun Limsukon © 2017, Medical Association of Thailand. All rights reserved. Objective: The present study intended to determine the risk factors of severe exacerbation in chronic obstructive pulmonary disease patients even though managed by pulmonologists on a regular basis. Material and Method: A retrospective case-controlled study was conducted at the chest clinic, Maharaj Nakorn Chiang Mai Hospital from 1st August 2009 to 31 st July 2010. The clinical relevant data for acute exacerbation (age, sex, co-morbidity, severity of COPD, COPD medication, annual influenza vaccination, compliance with inhaled drug use, chest radiographic abnormality, and long-term oxygen therapy) were compared between severe AECOPD and stable COPD patients by logistic regression analysis. Results: Out of 137 COPD patients, 17 (12.4%) had severe AECOPD with 29 episodes (21.2%). Six risk factors were identified, two modifiable and four non-modifiable. The two modifiable risk factors were annual influenza non-vaccination (odds ratio [OR] 27.79; 95% confidence interval [CI] , 2.29-337.66, p-value = 0.01) and improper use of inhaled devices (OR 9.94, 95%CI 1.07-92.54, p-value = 0.04). The four non-modifiable risk factors were age < 60 yrs (OR, 10.67; 95%CI, 1.92-59.31, p-value = 0.01), hypertension (OR, 4.03; 95%CI. 1.05-15.44, p-value = 0.04), enlarged pulmonary trunk as demonstrated by chest radiograph (OR, 8.61; 95%CI, 1.49-49.85, p-value = 0.02), and long-term oxygen therapy (OR, 7.09; 95%CI, 1.36-37.00, p-value = 0.02). Conclusion: Six risk factors of severe AECOPD among patients whom were provided regularly managed by pulmonologists were identified; two of them, annual influenza non-vaccination and improper use of inhaled devices, could be potentially modified. 2018-04-25T07:27:37Z 2018-04-25T07:27:37Z 2017-02-01 Journal 01252208 2-s2.0-85018684179 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018684179&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47242 |
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© 2017, Medical Association of Thailand. All rights reserved. Objective: The present study intended to determine the risk factors of severe exacerbation in chronic obstructive pulmonary disease patients even though managed by pulmonologists on a regular basis. Material and Method: A retrospective case-controlled study was conducted at the chest clinic, Maharaj Nakorn Chiang Mai Hospital from 1st August 2009 to 31 st July 2010. The clinical relevant data for acute exacerbation (age, sex, co-morbidity, severity of COPD, COPD medication, annual influenza vaccination, compliance with inhaled drug use, chest radiographic abnormality, and long-term oxygen therapy) were compared between severe AECOPD and stable COPD patients by logistic regression analysis. Results: Out of 137 COPD patients, 17 (12.4%) had severe AECOPD with 29 episodes (21.2%). Six risk factors were identified, two modifiable and four non-modifiable. The two modifiable risk factors were annual influenza non-vaccination (odds ratio [OR] 27.79; 95% confidence interval [CI] , 2.29-337.66, p-value = 0.01) and improper use of inhaled devices (OR 9.94, 95%CI 1.07-92.54, p-value = 0.04). The four non-modifiable risk factors were age < 60 yrs (OR, 10.67; 95%CI, 1.92-59.31, p-value = 0.01), hypertension (OR, 4.03; 95%CI. 1.05-15.44, p-value = 0.04), enlarged pulmonary trunk as demonstrated by chest radiograph (OR, 8.61; 95%CI, 1.49-49.85, p-value = 0.02), and long-term oxygen therapy (OR, 7.09; 95%CI, 1.36-37.00, p-value = 0.02). Conclusion: Six risk factors of severe AECOPD among patients whom were provided regularly managed by pulmonologists were identified; two of them, annual influenza non-vaccination and improper use of inhaled devices, could be potentially modified. |
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Journal |
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Chaicharn Pothirat Thatawan Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Athavudh Deesomchok Theerakorn Theerakittikul Atikun Limsukon |
spellingShingle |
Chaicharn Pothirat Thatawan Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Athavudh Deesomchok Theerakorn Theerakittikul Atikun Limsukon Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
author_facet |
Chaicharn Pothirat Thatawan Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Athavudh Deesomchok Theerakorn Theerakittikul Atikun Limsukon |
author_sort |
Chaicharn Pothirat |
title |
Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
title_short |
Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
title_full |
Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
title_fullStr |
Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
title_full_unstemmed |
Risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
title_sort |
risk factors of severe acute exacerbation of chronic obstructive pulmonary disease among patients regularly managed by pulmonologists |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018684179&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47242 |
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1681423024568401920 |