Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging

© Europa Digital & Publishing 2017. All rights reserved. The advent of intracoronary stents has greatly increased the safety and applicability of percutaneous coronary interventions. One of the drawbacks of drug-eluting stents (DES) is the increased risk of late and very late stent thrombosis...

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Main Authors: Yohei Sotomi, Pannipa Suwannasom, Patrick W. Serruys, Yoshinobu Onuma
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016011234&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47256
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-472562018-04-25T07:28:22Z Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging Yohei Sotomi Pannipa Suwannasom Patrick W. Serruys Yoshinobu Onuma © Europa Digital & Publishing 2017. All rights reserved. The advent of intracoronary stents has greatly increased the safety and applicability of percutaneous coronary interventions. One of the drawbacks of drug-eluting stents (DES) is the increased risk of late and very late stent thrombosis (ST). It was anticipated that the risks of ST after DES implantation would be solved with the advent of fully biodegradable scaffolds, which offer the possibility of transient scaffolding of the vessel to prevent acute vessel closure and recoil while also transiently eluting an antiproliferative drug to counteract constrictive remodelling and excessive neointimal hyperplasia. In spite of the enthusiasm for the concept of bioresorbable scaffolds, current clinical data on the Absorb bioresorbable vascular scaffold (BVS) have generated concerns about scaffold thrombosis (ScT) in both the early and late phases. However, the causes of ScT in both the early and late phases have yet to be fully elucidated. This article seeks to provide insights into the possible mechanical causes of ScT in the early and late phases with data stemming from intracoronary imaging (in travascular ultrasound and optical coherence tomography) of the currently published ScT cases following the implantation of BVS and reviews the practical recommendations for implantation of the BVS made by a group of experts. 2018-04-25T07:28:22Z 2018-04-25T07:28:22Z 2017-02-01 Journal 19696213 1774024X 2-s2.0-85016011234 10.4244/EIJ-D-16-00471 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016011234&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47256
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © Europa Digital & Publishing 2017. All rights reserved. The advent of intracoronary stents has greatly increased the safety and applicability of percutaneous coronary interventions. One of the drawbacks of drug-eluting stents (DES) is the increased risk of late and very late stent thrombosis (ST). It was anticipated that the risks of ST after DES implantation would be solved with the advent of fully biodegradable scaffolds, which offer the possibility of transient scaffolding of the vessel to prevent acute vessel closure and recoil while also transiently eluting an antiproliferative drug to counteract constrictive remodelling and excessive neointimal hyperplasia. In spite of the enthusiasm for the concept of bioresorbable scaffolds, current clinical data on the Absorb bioresorbable vascular scaffold (BVS) have generated concerns about scaffold thrombosis (ScT) in both the early and late phases. However, the causes of ScT in both the early and late phases have yet to be fully elucidated. This article seeks to provide insights into the possible mechanical causes of ScT in the early and late phases with data stemming from intracoronary imaging (in travascular ultrasound and optical coherence tomography) of the currently published ScT cases following the implantation of BVS and reviews the practical recommendations for implantation of the BVS made by a group of experts.
format Journal
author Yohei Sotomi
Pannipa Suwannasom
Patrick W. Serruys
Yoshinobu Onuma
spellingShingle Yohei Sotomi
Pannipa Suwannasom
Patrick W. Serruys
Yoshinobu Onuma
Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging
author_facet Yohei Sotomi
Pannipa Suwannasom
Patrick W. Serruys
Yoshinobu Onuma
author_sort Yohei Sotomi
title Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging
title_short Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging
title_full Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging
title_fullStr Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging
title_full_unstemmed Possible mechanical causes of scaffold thrombosis: Insights from case reports with intracoronary imaging
title_sort possible mechanical causes of scaffold thrombosis: insights from case reports with intracoronary imaging
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016011234&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47256
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