Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease

Objective: To compare red blood cell hematology among fetuses at risk of homozygous β-thalassemia disease at mid-pregnancy. Materials and Methods: Eighty-six fetuses, 18 to 22 gestational weeks, at risk of homozygous β-thalassemia disease undergoing cordocentesis between December 2010 and June 2012...

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Main Authors: Kasemsri Srisupundit, Chanane Wanapirak, Supatra Sirichotiyakul, Fuanglada Tongprasert, Suchaya Luewan, Kuntharee Traisrisilp, Theera Tongsong
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891609076&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47382
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-473822018-04-25T08:39:27Z Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease Kasemsri Srisupundit Chanane Wanapirak Supatra Sirichotiyakul Fuanglada Tongprasert Suchaya Luewan Kuntharee Traisrisilp Theera Tongsong Objective: To compare red blood cell hematology among fetuses at risk of homozygous β-thalassemia disease at mid-pregnancy. Materials and Methods: Eighty-six fetuses, 18 to 22 gestational weeks, at risk of homozygous β-thalassemia disease undergoing cordocentesis between December 2010 and June 2012 were recruited in the study. Red blood cell parameters were measured and final diagnosis of thalassemia status was based on fetal hemoglobin typing by high performance liquid chromatography technique and DNA analysis. The fetuses were categorized into 3 groups as normal β-globin genotype, β-thalassemia trait, and homozygous β-thalassemia disease. Results: Mean maternal age and mean gestational age were 26.56 ± 6.36 and 19.12 ± 1.06 weeks, respectively. The prevalence of fetuses with homozygous β-thalassemia disease, β-thalassemia trait, and normal β-globin genotype fetuses were 29.07% (25 cases), 20.93% (18 cases), and 50% (43 cases), respectively. All of red blood cell parameters were not significantly different among the 3 groups of fetuses. No affected fetus had anemia during midpregnancy. Conclusion: No significant difference in red blood cell parameters among unaffected and affected fetuses with homozygous β-thalassemia disease was found. Copyright © 2013 by Lippincott Williams & Wilkins. 2018-04-25T08:39:27Z 2018-04-25T08:39:27Z 2013-12-01 Journal 15363678 10774114 2-s2.0-84891609076 10.1097/MPH.0b013e3182a2717a https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891609076&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47382
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Objective: To compare red blood cell hematology among fetuses at risk of homozygous β-thalassemia disease at mid-pregnancy. Materials and Methods: Eighty-six fetuses, 18 to 22 gestational weeks, at risk of homozygous β-thalassemia disease undergoing cordocentesis between December 2010 and June 2012 were recruited in the study. Red blood cell parameters were measured and final diagnosis of thalassemia status was based on fetal hemoglobin typing by high performance liquid chromatography technique and DNA analysis. The fetuses were categorized into 3 groups as normal β-globin genotype, β-thalassemia trait, and homozygous β-thalassemia disease. Results: Mean maternal age and mean gestational age were 26.56 ± 6.36 and 19.12 ± 1.06 weeks, respectively. The prevalence of fetuses with homozygous β-thalassemia disease, β-thalassemia trait, and normal β-globin genotype fetuses were 29.07% (25 cases), 20.93% (18 cases), and 50% (43 cases), respectively. All of red blood cell parameters were not significantly different among the 3 groups of fetuses. No affected fetus had anemia during midpregnancy. Conclusion: No significant difference in red blood cell parameters among unaffected and affected fetuses with homozygous β-thalassemia disease was found. Copyright © 2013 by Lippincott Williams & Wilkins.
format Journal
author Kasemsri Srisupundit
Chanane Wanapirak
Supatra Sirichotiyakul
Fuanglada Tongprasert
Suchaya Luewan
Kuntharee Traisrisilp
Theera Tongsong
spellingShingle Kasemsri Srisupundit
Chanane Wanapirak
Supatra Sirichotiyakul
Fuanglada Tongprasert
Suchaya Luewan
Kuntharee Traisrisilp
Theera Tongsong
Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
author_facet Kasemsri Srisupundit
Chanane Wanapirak
Supatra Sirichotiyakul
Fuanglada Tongprasert
Suchaya Luewan
Kuntharee Traisrisilp
Theera Tongsong
author_sort Kasemsri Srisupundit
title Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
title_short Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
title_full Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
title_fullStr Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
title_full_unstemmed Fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
title_sort fetal red blood cell hematology at mid-pregnancy among fetuses at risk of homozygous β-thalassemia disease
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891609076&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47382
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