Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency

Thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are genetic disorders that cause hemolytic anemia. In areas with high frequencies of both hematological disorders, coinheritance of G-6-PD deficiency with thalassemia can be found. Whether G-6-PD deficiency, coinherited with thala...

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Main Authors: Sakorn Pornprasert, Siratcha Phanthong
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887218117&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47498
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spelling th-cmuir.6653943832-474982018-04-25T08:40:45Z Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency Sakorn Pornprasert Siratcha Phanthong Thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are genetic disorders that cause hemolytic anemia. In areas with high frequencies of both hematological disorders, coinheritance of G-6-PD deficiency with thalassemia can be found. Whether G-6-PD deficiency, coinherited with thalassemia, enhances severe anemia is still unclear. Hematological parameters between thalassemia carriers with G-6-PD deficiency and those without G-6-PD deficiency were compared. The G-6-PD deficiency was diagnosed in 410 blood samples from thalassemia patients using a fluorescent spot test. The levels of hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and Hb A2/Hb E [β26(B8)Glu→Lys; HBB: c.79G > A] were measured using an automated blood counter and high performance liquid chromatography (HPLC), respectively. The G-6-PD deficiency was found in 37 samples (9.02%). Mean levels of Hb, PCV, MCV and Hb A2/E were similar between the two groups. Thus, G-6-PD deficiency did not enhance red blood cell pathology or induce more anemic severity in thalassemia patients. © Informa Healthcare USA, Inc. 2018-04-25T08:40:45Z 2018-04-25T08:40:45Z 2013-11-13 Journal 1532432X 03630269 2-s2.0-84887218117 10.3109/03630269.2013.819558 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887218117&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47498
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are genetic disorders that cause hemolytic anemia. In areas with high frequencies of both hematological disorders, coinheritance of G-6-PD deficiency with thalassemia can be found. Whether G-6-PD deficiency, coinherited with thalassemia, enhances severe anemia is still unclear. Hematological parameters between thalassemia carriers with G-6-PD deficiency and those without G-6-PD deficiency were compared. The G-6-PD deficiency was diagnosed in 410 blood samples from thalassemia patients using a fluorescent spot test. The levels of hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and Hb A2/Hb E [β26(B8)Glu→Lys; HBB: c.79G > A] were measured using an automated blood counter and high performance liquid chromatography (HPLC), respectively. The G-6-PD deficiency was found in 37 samples (9.02%). Mean levels of Hb, PCV, MCV and Hb A2/E were similar between the two groups. Thus, G-6-PD deficiency did not enhance red blood cell pathology or induce more anemic severity in thalassemia patients. © Informa Healthcare USA, Inc.
format Journal
author Sakorn Pornprasert
Siratcha Phanthong
spellingShingle Sakorn Pornprasert
Siratcha Phanthong
Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
author_facet Sakorn Pornprasert
Siratcha Phanthong
author_sort Sakorn Pornprasert
title Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
title_short Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
title_full Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
title_fullStr Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
title_full_unstemmed Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
title_sort anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887218117&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47498
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